SMAD3 Antikörper (Middle Region)
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- Target Alle SMAD3 Antikörper anzeigen
- SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))
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Bindungsspezifität
- AA 193-222, Middle Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SMAD3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Verwendungszweck
- Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 3(SMAD3) detection. Tested with WB in Human.
- Sequenz
- DHQMNHSMDA GSPNLSPNPM SPAHNNLDLQ
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
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Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 3(SMAD3) detection. Tested with WB in Human.
Gene Name: SMAD family member 3
Protein Name: Mothers against decapentaplegic homolog 3 - Aufreinigung
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence in the middle region of human Smad3 (193-222aa DHQMNHSMDAGSPNLSPNPMSPAHNNLDLQ), identical to the related mouse and rat sequences.
- Isotyp
- IgG
- Top Product
- Discover our top product SMAD3 Primärantikörper
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- Applikationshinweise
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human , The detection limit for Smad3 is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Kommentare
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity." in: Archives of toxicology, Vol. 92, Issue 1, pp. 469-485, (2017) (PubMed).
: "NLRC5 Mediates IL-6 and IL-1? Secretion in LX-2 Cells and Modulated by the NF-?B/Smad3 Pathway." in: Inflammation, Vol. 38, Issue 5, pp. 1794-804, (2015) (PubMed).
: "Molecular responses of radiation-induced liver damage in rats." in: Molecular medicine reports, Vol. 11, Issue 4, pp. 2592-600, (2015) (PubMed).
: "Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-?, Smad3 and JAK-STAT pathway." in: International journal of clinical and experimental medicine, Vol. 7, Issue 9, pp. 2645-50, (2014) (PubMed).
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Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity." in: Archives of toxicology, Vol. 92, Issue 1, pp. 469-485, (2017) (PubMed).
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- Target
- SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))
- Andere Bezeichnung
- SMAD3 (SMAD3 Produkte)
- Synonyme
- HSPC193 antikoerper, HsT17436 antikoerper, JV15-2 antikoerper, LDS1C antikoerper, LDS3 antikoerper, MADH3 antikoerper, madh3 antikoerper, madh3a antikoerper, smad3 antikoerper, wu:fa99e03 antikoerper, XSmad3 antikoerper, XenMLP antikoerper, Xmad3 antikoerper, madh3-A antikoerper, Madh3 antikoerper, AU022421 antikoerper, Smad 3 antikoerper, mad3 antikoerper, madh3b antikoerper, zgc:92234 antikoerper, SMAD family member 3 antikoerper, SMAD family member 3a antikoerper, SMAD family member 3 L homeolog antikoerper, SMAD family member 3b antikoerper, SMAD3 antikoerper, smad3a antikoerper, smad3.L antikoerper, Smad3 antikoerper, smad3b antikoerper
- Hintergrund
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Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins. It is located in 15q22.33. And it mediates the signals from the transforming growth factor beta (TGF-β) super family ligands that regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.
Synonyms: DKFZP586N0721 antibody|DKFZp686J10186 antibody|hMAD 3 antibody|hMAD-3 antibody|hSMAD3 antibody|HSPC193 antibody|HST17436 antibody|JV15 2 antibody|JV15-2 antibody|JV152 antibody|JV152 antibody|LDS1C antibody|LDS3 antibody|MAD (mothers against decapentaplegic Drosophila) homolog 3 antibody|MAD (mothers against decapentaplegic Drosophila) homolog 3 antibody|MAD homolog 3 antibody|Mad homolog JV15 2 antibody|Mad protein homolog antibody|MAD, mothers against decapentaplegic homolog 3 antibody|MAD3 antibody|MAD3 antibody|MADH 3 antibody|MADH3 antibody|MADH3 antibody|MGC60396 antibody|Mothers against decapentaplegic homolog 3 antibody|Mothers against DPP homolog 3 antibody|Mothers against DPP homolog 3 antibody|SMA and MAD related protein 3 antibody|SMAD 3 antibody|SMAD antibody|SMAD family member 3 antibody|SMAD, mothers against DPP homolog 3 antibody|SMAD3 antibody|SMAD3_HUMAN antibody - Gen-ID
- 4088
- UniProt
- P84022
- Pathways
- Zellzyklus, Chromatin Binding, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Autophagie
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