Angiotensin I Converting Enzyme 1 Antikörper (Middle Region)

Produktnummer ABIN3042841

Produktdetails anti-Angiotensin I Converting Enzyme 1 Antikörper

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Bindungsspezifität: AA 702-715, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Angiotensin I Converting Enzyme 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Angiotensin-converting enzyme(ACE) detection. Tested with WB, IHC-P in Human.

Sequenz: TQARKFDVNQ LQNT

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Angiotensin-converting enzyme(ACE) detection. Tested with WB, IHC-P in Human.
Gene Name: angiotensin I converting enzyme
Protein Name: Angiotensin-converting enzyme

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Angiotensin Converting Enzyme 1(702-715aa TQARKFDVNQLQNT).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-Angiotensin I Converting Enzyme 1 Antikörper (ABIN3042841)

Yan, Shen: "Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 3965-3973, (2018) (PubMed).

Details zu Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Andere Bezeichnung: ACE (ACE Produkte)

Synonyme: ACE1 antikoerper, CD143 antikoerper, DCP antikoerper, DCP1 antikoerper, ICH antikoerper, MVCD3 antikoerper, AW208573 antikoerper, Dcp1 antikoerper, StsRR92 antikoerper, dcp antikoerper, ace1 antikoerper, dcp1 antikoerper, xace antikoerper, cd143 antikoerper, ACE antikoerper, angiotensin I converting enzyme antikoerper, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 antikoerper, angiotensin-converting enzyme antikoerper, angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 antikoerper, angiotensin-converting enzyme-like antikoerper, ACE antikoerper, Ace antikoerper, ace antikoerper, CpipJ_CPIJ009106 antikoerper, ACE3 antikoerper, LOC101824864 antikoerper

Hintergrund: Angiotensin I converting enzyme(ACE), also called DCP or CD143, is a zinc-containing dipeptidyl carboxypeptidase widely distributed in mammalian tissues and is though to play a critical role in blood pressure regulation. ACE gene is mapped to 17q23.3. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies.

Synonyms: ACE 1 antibody|ACE antibody|ACE T antibody|ACE_HUMAN antibody|ACE1 antibody|Angiotensin converting enzyme somatic isoform antibody|Angiotensin converting enzyme testis specific isoform antibody|Angiotensin I converting enzyme 1 antibody|Angiotensin I converting enzyme antibody|Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody|Angiotensin-converting enzyme antibody|Carboxycathepsin antibody|CD 143 antibody|CD143 antibody|CD143 antigen antibody|DCP 1 antibody|DCP antibody|DCP1 antibody|Dipeptidyl carboxypeptidase 1 antibody|Dipeptidyl carboxypeptidase I antibody|Kininase II antibody|MGC26566 antibody|MVCD3 antibody|Peptidase P antibody|Peptidyl dipeptidase A antibody|soluble form antibody|Testicular ECA antibody

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration