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Retinoblastoma 1 Antikörper (pSer811)

Name: Retinoblastoma 1 Antikörper (pSer811)
Brand: antibodies-online
SKU: ABIN3023610
Price: 849.42 EUR
Availability: InStock

RB1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated

Western Blotting (WB) image for anti-Retinoblastoma 1 (RB1) (pSer811) antibody (ABIN3023610) (Retinoblastoma 1 Antikörper (pSer811))

Immunofluorescence analysis of U2OS cells using Phospho-Rb-S811 antibody. (Retinoblastoma 1 Antikörper (pSer811))

Western blot analysis of extracts of 293 and HeLa cells, using Phospho-Rb-S811 antibody. (Retinoblastoma 1 Antikörper (pSer811))

MiR-188 arrests cell cycle at G1/S transition through negative regulation of Rb-E2F axis. (Retinoblastoma 1 Antikörper (pSer811))

MiR-188 suppresses tumor initiation and progressionin vivo. (Retinoblastoma 1 Antikörper (pSer811))

6 Abbildungen

(1 reference)

Produktnummer ABIN3023610

Datenblatt (PDF)

Target Alle Retinoblastoma 1 (RB1) Antikörper anzeigen

Retinoblastoma 1 (RB1)
Bindungsspezifität
36

29

26

25

23

21

19

15

11

10

10

7

6

6

4

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer811
Reaktivität
280

119

101

6

4

4

4

3

3

3

2

1

1

1
Human
Wirt
247

36
Kaninchen
Passende Sekundärantikörper
Klonalität
238

45
Polyklonal
Konjugat
134

19

17

16

11

10

8

8

6

6

6

6

6

6

6

6

6

1

1

1

1

1

1
Dieser Retinoblastoma 1 Antikörper ist unkonjugiert
Applikation
212

121

110

80

79

40

33

28

28

20

16

8

7

6

6

6

4

2

1
Western Blotting (WB)

Sequenz

LKSPY

Kreuzreaktivität

Human

Produktmerkmale

Phosphorylated Antibodies

Aufreinigung

Affinity purification

Immunogen

A synthetic phosphorylated peptide around S811 of human RB (NP_000312.2).

Isotyp

IgG

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Applikationshinweise

WB,1:1000 - 1:2000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Avoid freeze / thaw cycles

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20°C. Avoid freeze / thaw cycles.
Wu, Lv, He, Zhang, Mei, Cui, Huang, Xie, Xu, Zhang: "MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes." in: Cell communication and signaling : CCS, Vol. 12, pp. 66, (2015) (PubMed).
Target

Retinoblastoma 1 (RB1)

Andere Bezeichnung

RB1 (RB1 Produkte)

Synonyme

OSRC antikoerper, RB antikoerper, p105-Rb antikoerper, pRb antikoerper, pp110 antikoerper, Rb antikoerper, Rb-1 antikoerper, P105-RB antikoerper, PP110 antikoerper, RB11 antikoerper, zgc:154147 antikoerper, RB transcriptional corepressor 1 antikoerper, RB transcriptional corepressor like 1 antikoerper, retinoblastoma 1 antikoerper, RB1 antikoerper, RBL1 antikoerper, Rb1 antikoerper, rb1 antikoerper

Hintergrund

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.,OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Rb,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,Protein phosphorylation,RB1

Molekulargewicht

106 kDa

Gen-ID

5925

UniProt

P06400

Pathways

Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagie