PRKAR1A Antikörper (C-Term)

Produktnummer ABIN2787418

Produktdetails anti-PRKAR1A Antikörper

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Schaf, Rind (Kuh), Kaninchen, Pferd, Zebrafisch (Danio rerio), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKAR1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MNRPRAATVV ARGPLKCVKL DRPRFERVLG PCSDILKRNI QQYNSFVSLS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PRKAR1A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PRKAR1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 381 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PRKAR1A

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Andere Bezeichnung: PRKAR1A (PRKAR1A Produkte)

Synonyme: ACRDYS1 antikoerper, ADOHR antikoerper, CAR antikoerper, CNC antikoerper, CNC1 antikoerper, PKR1 antikoerper, PPNAD1 antikoerper, PRKAR1 antikoerper, TSE1 antikoerper, 1300018C22Rik antikoerper, RIalpha antikoerper, Tse-1 antikoerper, Tse1 antikoerper, RIIA antikoerper, prkar1a antikoerper, zgc:92515 antikoerper, im:7047729 antikoerper, cnc1 antikoerper, pkr1 antikoerper, ppnad1 antikoerper, prkar1 antikoerper, tse1 antikoerper, protein kinase cAMP-dependent type I regulatory subunit alpha antikoerper, protein kinase, cAMP dependent regulatory, type I, alpha antikoerper, protein kinase cAMP-dependent type 1 regulatory subunit alpha antikoerper, protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a antikoerper, cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene antikoerper, protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog antikoerper, PRKAR1A antikoerper, Prkar1a antikoerper, prkar1aa antikoerper, LOC707275 antikoerper, prkar1a.S antikoerper

Hintergrund: CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.
Alias Symbols: CAR, CNC, CNC1, DKFZp779L0468, MGC17251, PKR1, PPNAD1, PRKAR1, TSE1, ADOHR
Protein Interaction Partner: UBC, RAF1, MAPT, CEP250, GSK3B, AGO3, AGO2, ARPC3, PFDN5, DYRK1B, SET, DYRK1A, PLEKHF2, AKAP10, SOX2, PRKACB, PRKACA, NPM1, CAPN11, RFC2, PPP1CA, SMAD2, HIVEP1, SETD7, PRPF40A, CDK2, CCNE1, SMURF1, Akap7, MEN1, HSP90AA4P, SLC38A5, PRPF31, SAFB, UBD, PATZ1
Protein Size: 381

Molekulargewicht: 43 kDa

Gen-ID: 5573

NCBI Accession: NM_212471, NP_997636

UniProt: P10644

Pathways: Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma