PRKAR1A Produkte
(Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
Kategorien
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013].
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Ausgewählte PRKAR1A Kategorien
PRKAR1A Antikörper
High quality antibodies with extensive validation data.
PRKAR1A Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PRKAR1A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (5)
Kat. Nr.
ABIN3021148
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, IF, ICC
Validierungen
- (3)
Kat. Nr.
ABIN6264423
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN5518788
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene PRKAR1A ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN5648035
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730540
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PRKAR1A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316241
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316243
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Human Cells
Validierungen
Kat. Nr.
ABIN7318228
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PRKAR1A Produkten
: "Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion." in: Hepatology (Baltimore, Md.), Vol. 68, Issue 4, pp. 1441-1447, (2019) (PubMed).: "Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 29, Issue 6, pp. 607-15, (2018) (PubMed).
: "Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex." in: Scientific reports, Vol. 6, pp. 33557, (2016) (PubMed).
: "Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors." in: Endocrine-related cancer, Vol. 22, Issue 3, pp. 399-408, (2015) (PubMed).
: "PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors." in: The American journal of surgical pathology, Vol. 38, Issue 8, pp. 1079-87, (2014) (PubMed).
: "An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 190, Issue 1, pp. 51-61, (2014) (PubMed).
: "MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer." in: Molecular cancer, Vol. 13, pp. 239, (2014) (PubMed).
: "Rapid generation of a mouse model for Middle East respiratory syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 13, pp. 4970-5, (2014) (PubMed).
: "Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension." in: Science translational medicine, Vol. 5, Issue 200, pp. 200ra117, (2013) (PubMed).
: "Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2V?2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 3, pp. 1029-42, (2013) (PubMed).
Synonyme und alternative Namen zu PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A), protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a), protein kinase cAMP-dependent type 1 regulatory subunit alpha (Prkar1a), protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (prkar1aa), cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene (LOC707275), protein kinase cAMP-dependent type I regulatory subunit alpha (Prkar1a), protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog (prkar1a.S), 1300018C22Rik, ACRDYS1, ADOHR, CAR, CNC, CNC1, cnc1, im:7047729, PKR1, pkr1, PPNAD1, ppnad1, PRKAR1, prkar1, prkar1a, RIalpha, RIIA, Tse-1, TSE1, Tse1, tse1, zgc:92515Bezeichner auf Proteinebene für PRKAR1A
- cAMP-dependent protein kinase regulatory subunit RIalpha
- cAMP-dependent protein kinase type I-alpha regulatory chain
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- protein kinase A type 1a regulatory subunit
- tissue-specific extinguisher 1
- protein kinase, cAMP dependent regulatory, type 1, alpha
- protein kinase, cAMP dependent regulatory, type I, alpha
- cAMP-dependent protein kinase type I regulatory subunit
- protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
- cAMP-dependent protein kinase, regulatory subunit alpha 1
- cAMP-dependent protein kinase regulatory subunit alpha 1
- cAMP-dependent protein kinase type I-alpha regulatory subunit-like
- protein kinase, cAMP-dependent, regulatory subunit type I alpha S homeolog
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