ACRDYS1 antikoerper, ADOHR antikoerper, CAR antikoerper, CNC antikoerper, CNC1 antikoerper, PKR1 antikoerper, PPNAD1 antikoerper, PRKAR1 antikoerper, TSE1 antikoerper, 1300018C22Rik antikoerper, RIalpha antikoerper, Tse-1 antikoerper, Tse1 antikoerper, RIIA antikoerper, prkar1a antikoerper, zgc:92515 antikoerper, im:7047729 antikoerper, cnc1 antikoerper, pkr1 antikoerper, ppnad1 antikoerper, prkar1 antikoerper, tse1 antikoerper, protein kinase cAMP-dependent type I regulatory subunit alpha antikoerper, protein kinase, cAMP dependent regulatory, type I, alpha antikoerper, protein kinase cAMP-dependent type 1 regulatory subunit alpha antikoerper, protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a antikoerper, cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene antikoerper, protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog antikoerper, PRKAR1A antikoerper, Prkar1a antikoerper, prkar1aa antikoerper, LOC707275 antikoerper, prkar1a.S antikoerper
Hintergrund
CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.,PRKAR1A,ACRDYS1,ADOHR,CAR,CNC,CNC1,PKR1,PPNAD1,PRKAR1,TSE1,Cancer,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Serine/threonine kinases,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Cytoskeleton,Microtubules,Actins,Hedgehog Signaling Pathway,Endocrine & Metabolism,AMPK Signaling Pathway,Insulin Receptor Signaling Pathway,Immunology & Inflammation,Neuroscience,Neurodegenerative Diseases,Dopamine Signaling in Parkinson's Disease,PRKAR1A