PRKAA2 Produkte
(Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2))
Kategorien
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
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Ausgewählte PRKAA2 Kategorien
PRKAA2 Antikörper
High quality antibodies with extensive validation data.
PRKAA2 ELISA Kits
Reliable ELISA kits for a wide range of species.
PRKAA2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PRKAA2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Monkey
Applikation
WB, ELISA, IHC, FACS, ICC, Neut
Validierungen
- (7)
Kat. Nr.
ABIN5611223
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF, IHC (p), IP, ICC
Validierungen
- (3)
- (5)
Kat. Nr.
ABIN2855639
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, RNAi, PLA
Validierungen
- (6)
Kat. Nr.
ABIN519168
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene PRKAA2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969726
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1119510
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Pig
Analytical Method
Validierungen
Kat. Nr.
ABIN1119511
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PRKAA2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5569698
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Rat
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7321284
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124658
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PRKAA2 Produkten
: "Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2." in: Redox biology, Vol. 28, pp. 101345, (2020) (PubMed).: "The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect." in: PLoS ONE, Vol. 14, Issue 3, pp. e0213779, (2019) (PubMed).
: "Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice." in: Scientific reports, Vol. 8, Issue 1, pp. 6462, (2018) (PubMed).
: "Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 680-686, (2017) (PubMed).
: "LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress." in: Nature cell biology, Vol. 18, Issue 4, pp. 431-42, (2016) (PubMed).
: "AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration." in: The Journal of biological chemistry, Vol. 290, Issue 44, pp. 26445-56, (2015) (PubMed).
: "High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1)." in: The Journal of biological chemistry, Vol. 290, Issue 14, pp. 9183-94, (2015) (PubMed).
: "Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells." in: Breast cancer research : BCR, Vol. 16, Issue 4, pp. 420, (2015) (PubMed).
: "Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo." in: Nature medicine, Vol. 18, Issue 6, pp. 902-10, (2012) (PubMed).
: "Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK." in: Nature, Vol. 482, Issue 7384, pp. 251-5, (2012) (PubMed).
Synonyme und alternative Namen zu PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2), protein kinase AMP-activated catalytic subunit alpha 2 (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog (prkaa2.S), protein kinase, AMP-activated, alpha 2 catalytic subunit (prkaa2), 2310008I11Rik, A830082D05, AMPK, Ampk, ampk, AMPK2, ampk2, AMPKa2, Ampka2, AMPKA2, AMPKalpha2, PRKAA, prkaa, prkaa1, PRKAA2Bezeichner auf Proteinebene für PRKAA2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- 5'-AMP-activated protein kinase, catalytic alpha-2 chain
- ACACA kinase
- AMPK subunit alpha-2
- AMPK-alpha-2 chain
- HMGCR kinase
- acetyl-CoA carboxylase kinase
- hydroxymethylglutaryl-CoA reductase kinase
- AMP-activated protein kinase
- AMPK alpha-2 chain
- AMP-activated protein kinase alpha-2 variant B
- AMP-activated protein kinase alpha 2
- protein kinase AMP-activated alpha 2 catalytic subunit
- SNF1-like protein AMPK
- 5'-AMP-activated protein kinase alpha-2 catalytic subunit
- AMPKalpha2
- ampka2
- AMP-activated protein kinase alpha 2 catalytic subunit
- protein kinase, AMP-activated, alpha 2 catalytic subunit
- AMPK-activated protein kinase alpha-2 subunit
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