MLH1 Antikörper (N-Term)
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- Target Alle MLH1 Antikörper anzeigen
- MLH1 (MutL Homolog 1 (MLH1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Saccharomyces cerevisiae
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MLH1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- MIENCLDAKS TSIQVIVKEG GLKLIQIQDN GTGIRKEDLD IVCERFTTSK
- Homologie
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%, Zebrafish: 79%
- Produktmerkmale
- This is a rabbit polyclonal antibody against MLH1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human MLH1
- Top Product
- Discover our top product MLH1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 756 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MLH1 (MutL Homolog 1 (MLH1))
- Andere Bezeichnung
- MLH1 (MLH1 Produkte)
- Synonyme
- CG11482 antikoerper, Dmel\\CG11482 antikoerper, dmlh-1 antikoerper, dmlh1 antikoerper, zgc:66301 antikoerper, MLH1 antikoerper, LOC100232198 antikoerper, 1110035C23Rik antikoerper, AI317206 antikoerper, AI325952 antikoerper, AI561766 antikoerper, COCA2 antikoerper, FCC2 antikoerper, HNPCC antikoerper, HNPCC2 antikoerper, hMLH1 antikoerper, mutL homolog 1 antikoerper, CG11482 gene product from transcript CG11482-RB antikoerper, mutL homolog 1 S homeolog antikoerper, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) antikoerper, DNA mismatch repair protein Mlh1 antikoerper, MLH1 antikoerper, Mlh1 antikoerper, mlh1.S antikoerper, mlh1 antikoerper, LOC588545 antikoerper
- Hintergrund
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This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COCA2, FCC2, HNPCC, HNPCC2, MGC5172, hMLH1
Protein Interaction Partner: SPERT, CXorf57, PSMA1, MYOG, MSH3, KPNA2, MLH3, ZC3H11A, EXO1, PMS2, MMS19, PCNA, DES, CTSB, ATF2, CKB, CAPN5, ASS1, TRIM23, ARAF, APRT, ANXA6, ANXA2, ALDOA, ACTG2, ACTG1, TXN2, GABARAP, EXOC3, CKAP4, AGR2, ZER1, NDRG1, AIFM1, SELENBP1, SQSTM1, FCGBP, ABC
Protein Size: 756 - Molekulargewicht
- 84 kDa
- Gen-ID
- 4292
- NCBI Accession
- NM_000249, NP_000240
- UniProt
- P40692
- Pathways
- DNA Reparatur, Production of Molecular Mediator of Immune Response
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