MLH1 Antikörper (AA 381-483)
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- Target Alle MLH1 Antikörper anzeigen
- MLH1 (MutL Homolog 1 (MLH1))
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Bindungsspezifität
- AA 381-483
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser MLH1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human MLH1 (AA: 381-483) expressed in E. coli.
- Klon
- 8C12B7
- Isotyp
- IgG2b
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anti-MutL Homolog 1 (MLH1) (AA 381-483) antibody
MLH1 Reaktivität: Human WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 7A7C8 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 1-756) antibodyMLH1 Reaktivität: Human WB, ELISA, IF, IHC (p), PLA Wirt: Maus Monoclonal M1 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 350-519) antibodyMLH1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 381-483) antibodyMLH1 Reaktivität: Human, Affe WB, ELISA, IHC, ICC Wirt: Maus Monoclonal 4C9C7 unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 Reaktivität: Human, Maus WB, IP Wirt: Maus Monoclonal G168-728 unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 Reaktivität: Human WB, IHC (p), IHC (fro) Wirt: Maus Monoclonal G168 unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 501-600) antibodyMLH1 Reaktivität: Human ELISA, IHC (p), IF (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB:1:500 - 1:2000, ICC:1:200 - 1:1000, FCM:1:200 - 1:400, ELISA:1:10000,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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- Target
- MLH1 (MutL Homolog 1 (MLH1))
- Andere Bezeichnung
- MLH1 (MLH1 Produkte)
- Synonyme
- CG11482 antikoerper, Dmel\\CG11482 antikoerper, dmlh-1 antikoerper, dmlh1 antikoerper, zgc:66301 antikoerper, MLH1 antikoerper, LOC100232198 antikoerper, 1110035C23Rik antikoerper, AI317206 antikoerper, AI325952 antikoerper, AI561766 antikoerper, COCA2 antikoerper, FCC2 antikoerper, HNPCC antikoerper, HNPCC2 antikoerper, hMLH1 antikoerper, mutL homolog 1 antikoerper, CG11482 gene product from transcript CG11482-RB antikoerper, mutL homolog 1 S homeolog antikoerper, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) antikoerper, DNA mismatch repair protein Mlh1 antikoerper, MLH1 antikoerper, Mlh1 antikoerper, mlh1.S antikoerper, mlh1 antikoerper, LOC588545 antikoerper
- Hintergrund
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Description: The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
Aliases: FCC2, COCA2, HNPCC, hMLH1, HNPCC2
- Molekulargewicht
- 84.6 kDa
- Gen-ID
- 4292
- Pathways
- DNA Reparatur, Production of Molecular Mediator of Immune Response
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