TRKA Antikörper (pTyr680, pTyr681)

Produktnummer ABIN2568517

Produktdetails anti-TRKA Antikörper

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Bindungsspezifität: pTyr680, pTyr681

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRKA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects endogenous level of Trk A only when phosphorylated at tyrosine 680/tyrosine 681.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Trk A (phospho Tyr680/681) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y (p)-Y (p)-R-V) derived from Human Trk A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu TRKA

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Andere Bezeichnung: Trk A (NTRK1 Produkte)

Synonyme: MTC antikoerper, TRK antikoerper, TRK1 antikoerper, TRKA antikoerper, Trk-A antikoerper, p140-TrkA antikoerper, CDHF12 antikoerper, CDHR16 antikoerper, HSCR1 antikoerper, MEN2A antikoerper, MEN2B antikoerper, MTC1 antikoerper, PTC antikoerper, RET-ELE1 antikoerper, RET51 antikoerper, Trk antikoerper, C80751 antikoerper, Tkr antikoerper, TrkA antikoerper, trk antikoerper, trka antikoerper, CTRKA antikoerper, trkA antikoerper, neurotrophic receptor tyrosine kinase 1 antikoerper, ret proto-oncogene antikoerper, neurotrophic tyrosine kinase, receptor, type 1 antikoerper, NTRK1 antikoerper, RET antikoerper, Ntrk1 antikoerper, ntrk1 antikoerper

Hintergrund: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Molekulargewicht: 87 kDa

Gen-ID: 4914

NCBI Accession: NP_001007793

UniProt: P04629

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process