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PAK1 Antikörper (pSer204)
PAK1
Reaktivität: Human, Ratte, Maus
WB, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2568413
Produktdetails anti-PAK1 Antikörper
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Target
Alle PAK1 Antikörper anzeigen
PAK1
(P21-Activated Kinase 1 (PAK1))
Bindungsspezifität
Alle Epitope für PAK1 Antikörper
pSer204
Reaktivität
Alle Reaktivitäten für PAK1 Antikörper
Human, Ratte, Maus
Wirt
Alle Wirte für PAK1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für PAK1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für PAK1 Antikörper
Dieser PAK1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für PAK1 Antikörper
Western Blotting (WB), Immunohistochemistry (IHC)
Spezifität
The antibody detects endogenous levels of PAK1 only when phosphorylated at serine 204.
Aufreinigung
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
PAK1 (phospho Ser204) antibody was raised against a peptide sequence around phosphorylation site of Serine 204 (T-R-S (p)-V-I) derived from Human PAK1.
Isotyp
IgG
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store antibody at -20°C for up to one year.
Details zu PAK1
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Target
PAK1
(P21-Activated Kinase 1 (PAK1))
Andere Bezeichnung
PAK1 (PAK1 Produkte )
Synonyme
X-PAK1 antikoerper, XPak1 antikoerper, pak antikoerper, pak-1 antikoerper, pakalpha antikoerper, PAKalpha antikoerper, AW045634 antikoerper, PAK-1 antikoerper, Paka antikoerper, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antikoerper, p21 (RAC1) activated kinase 1 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 1 antikoerper, Serine/threonine-protein kinase pak-1 antikoerper, pak1.S antikoerper, PAK1 antikoerper, Pak1 antikoerper, pak-1 antikoerper
Hintergrund
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Molekulargewicht
65 kDa
Gen-ID
5058
NCBI Accession
NP_002567
UniProt
Q13153
Pathways
MAPK Signalweg , RTK Signalweg , T-Zell Rezeptor Signalweg , Fc-epsilon Rezeptor Signalübertragung , Intracellular Steroid Hormone Receptor Signaling Pathway , Regulation of Intracellular Steroid Hormone Receptor Signaling , Skeletal Muscle Fiber Development , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , Embryonic Body Morphogenesis
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