Cyclin H Antikörper (pThr315)

Produktnummer ABIN2568091

Produktdetails anti-Cyclin H Antikörper

Target: Cyclin H (CCNH)

Bindungsspezifität: pThr315

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects endogenous levels of Cyclin H only when phosphorylated at threonine 315.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Cyclin H (phospho Thr315) antibody was raised against a peptide sequence around phosphorylation site of threonine 315 (E-W-T (p)-D-D) derived from Human Cyclin H .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu Cyclin H

Target: Cyclin H (CCNH)

Andere Bezeichnung: Cyclin H (CCNH Produkte)

Synonyme: zgc:114132 antikoerper, cak antikoerper, p34 antikoerper, p37 antikoerper, Cych antikoerper, ACYPI004637 antikoerper, ccnh antikoerper, Cyclin-H antikoerper, 142767_at antikoerper, CG7405 antikoerper, Dmel\\CG7405 antikoerper, CAK antikoerper, 6330408H09Rik antikoerper, AI661354 antikoerper, AV102684 antikoerper, AW538719 antikoerper, ccnh-A antikoerper, cyclin H antikoerper, cyclin-H antikoerper, Cyclin H antikoerper, CYclin H antikoerper, cyclin H L homeolog antikoerper, CCNH antikoerper, ccnh antikoerper, LOC5577539 antikoerper, Cych antikoerper, CycH antikoerper, cyh-1 antikoerper, Ccnh antikoerper, ccnh.L antikoerper

Hintergrund: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Molekulargewicht: 36 kDa

Gen-ID: 902

NCBI Accession: NP_001230

UniProt: P51946

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, M Phase