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CDK1 Antikörper (pThr14)
CDK1
Reaktivität: Human, Maus, Ratte
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2568068
Produktdetails anti-CDK1 Antikörper
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Target
Alle CDK1 Antikörper anzeigen
CDK1
(Cyclin-Dependent Kinase 1 (CDK1))
Bindungsspezifität
Alle Epitope für CDK1 Antikörper
pThr14
Reaktivität
Alle Reaktivitäten für CDK1 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für CDK1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für CDK1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für CDK1 Antikörper
Dieser CDK1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CDK1 Antikörper
Western Blotting (WB)
Spezifität
The antibody detects endogenous level of CDK1/CDC2 only when phosphorylated at threonine 14.
Aufreinigung
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
CDK1/CDC2 (phospho Thr14) antibody was raised against a peptide sequence around phospho rylation site of threonine14 (E-G-T (p)-Y-G) derived from Human CDK1/CDC2 .
Isotyp
IgG
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Discover our top product CDK1 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1:500~1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store antibody at -20°C for up to one year.
Details zu CDK1
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Target
CDK1
(Cyclin-Dependent Kinase 1 (CDK1))
Andere Bezeichnung
CDK1/CDC2 (CDK1 Produkte )
Synonyme
CDC2 antikoerper, CDC28A antikoerper, P34CDC2 antikoerper, Cdc2 antikoerper, Cdc2a antikoerper, p34 antikoerper, cdc2 antikoerper, wu:fc30e01 antikoerper, zgc:92032 antikoerper, PSTAIR antikoerper, cdc-2 antikoerper, cdc2-a antikoerper, cdc28a antikoerper, cdc2x1.1 antikoerper, p34cdc2 antikoerper, xcdc2 antikoerper, 5363 antikoerper, CDCDm antikoerper, CDK1 antikoerper, CDK1/CDC2 antikoerper, CG5363 antikoerper, Cdk-1 antikoerper, Cdk1 antikoerper, Dcdc2 antikoerper, Dm cdc2 antikoerper, DmCdc2 antikoerper, DmCdk1 antikoerper, Dmcdc2 antikoerper, Dmel\\CG5363 antikoerper, cdc antikoerper, cdc2Dm antikoerper, cdk1 antikoerper, dCdk1 antikoerper, group 4 antikoerper, l(2)31Eh antikoerper, CDC2A antikoerper, CDC2AAT antikoerper, CDK2 antikoerper, CDKA1 antikoerper, CDKA;1 antikoerper, CYCLIN-DEPENDENT KINASE A;1 antikoerper, cell division control 2 antikoerper, cdc2-b antikoerper, cdc2a antikoerper, cdc2x1.2 antikoerper, POL3 antikoerper, pold antikoerper, cyclin dependent kinase 1 antikoerper, cyclin dependent kinase like 1 antikoerper, Cell division control protein 2 1 antikoerper, cyclin-dependent kinase 1 antikoerper, cyclin-dependent kinase 1 S homeolog antikoerper, Cyclin-dependent kinase 1 antikoerper, cell division control 2 antikoerper, cell division control protein2 homolog antikoerper, cyclin-dependent kinase 1 L homeolog antikoerper, polymerase (DNA directed), delta 1, catalytic subunit L homeolog antikoerper, cyclin-dependent protein kinase Cdk1/Cdc2 antikoerper, CDK1 antikoerper, CDKL1 antikoerper, POPTR_0004s14080g antikoerper, Cdk1 antikoerper, cdk1 antikoerper, cdk1.S antikoerper, CDC2 antikoerper, cdc2 antikoerper, cdk-1 antikoerper, cdk1.L antikoerper, pold1.L antikoerper
Hintergrund
Serine/threonine-protein kinase involved in the control of the cell cycle, essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.
Molekulargewicht
34 kDa
Gen-ID
1017
NCBI Accession
NP_001277159
UniProt
P24941
Pathways
Zellzyklus , Fc-epsilon Rezeptor Signalübertragung , Neurotrophin Signalübertragung , Activation of Innate immune Response , Mitotic G1-G1/S Phases , DNA Replication , M Phase , Toll-Like Receptors Cascades , Synthesis of DNA
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