HSD11B2 Antikörper (AA 181-405)

Produktnummer ABIN2468177

Produktdetails anti-HSD11B2 Antikörper

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Bindungsspezifität: AA 181-405

Reaktivität: Human, Ratte, Huhn

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser HSD11B2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Immunoaffinity Purified

Anwendungsinformationen

Applikationshinweise: Corticosteroid 11-beta-dehydrogenase, isozyme 2 antibody can be used for the detection of Corticosteroid 11-beta-dehydrogenase, isozyme 2 by Western Blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Konservierungsmittel: Without preservative

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: HSD11B2 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Details zu HSD11B2

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Andere Bezeichnung: HSD11B2 (HSD11B2 Produkte)

Synonyme: MGC81883 antikoerper, 11-HSD2 antikoerper, AME antikoerper, AME1 antikoerper, HSD11K antikoerper, HSD2 antikoerper, SDR9C3 antikoerper, 11HSD2 antikoerper, HSD11B2 antikoerper, hydroxysteroid (11-beta) dehydrogenase 2 L homeolog antikoerper, hydroxysteroid 11-beta dehydrogenase 2 antikoerper, hsd11b2.L antikoerper, HSD11B2 antikoerper, Hsd11b2 antikoerper

Hintergrund: FUNCTION: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

DISEASE: Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.

Molekulargewicht: 44.1 kDa (calculated)

Gen-ID: 3291

NCBI Accession: NP_000187

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones