TAF1 Antikörper (C-Term)

Produktnummer ABIN233826

Produktdetails anti-TAF1 Antikörper

Target: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the of human TAF1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 213 kDa in size corresponding to TAF1 protein by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.15 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-TAF1 Antikörper (ABIN233826)

Gegonne, Tai, Zhang, Wu, Zhu, Yoshimoto, Hanson, Cultraro, Chen, Guinter, Yang, Hathcock, Singer, Rodriguez-Canales, Tessarollo, Mackem, Meerzaman, Buetow, Singer: "The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells." in: Molecular and cellular biology, Vol. 32, Issue 10, pp. 1984-97, (2012) (PubMed).

Details zu TAF1

Target: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Andere Bezeichnung: TAF1 (TAF1 Produkte)

Synonyme: BG:DS00004.13 antikoerper, CG17603 antikoerper, Dmel\\CG17603 antikoerper, EfW1 antikoerper, SR3-5 antikoerper, TAF antikoerper, TAF1 antikoerper, TAF200 antikoerper, TAF230 antikoerper, TAF250 antikoerper, TAF250/230 antikoerper, TAFII-250 antikoerper, TAFII250 antikoerper, TAF[II]250 antikoerper, TAF[[II]] antikoerper, TAF[[II]]230 antikoerper, TAF[[II]]250 antikoerper, TAF[[II]]250/230 antikoerper, TFIID antikoerper, TFIID TAF250 antikoerper, Taf1p antikoerper, Taf200 antikoerper, Taf230 antikoerper, Taf250 antikoerper, Taf[[II]]250 antikoerper, cel antikoerper, cell antikoerper, d230 antikoerper, dTAF230 antikoerper, dTAF250 antikoerper, dTAFII250 antikoerper, dTAF[[II]]230 antikoerper, dTAF[[II]]250 antikoerper, dmTAF1 antikoerper, dmTAF[[II]]230 antikoerper, l(3)84Ab antikoerper, p230 antikoerper, 250kDa antikoerper, AU015687 antikoerper, B430306D02Rik antikoerper, Ccg-1 antikoerper, Ccg1 antikoerper, KAT4 antikoerper, N-TAF1 antikoerper, Taf2a antikoerper, RGD1562050 antikoerper, BA2R antikoerper, CCG1 antikoerper, CCGS antikoerper, DYT3 antikoerper, DYT3/TAF1 antikoerper, NSCL2 antikoerper, OF antikoerper, P250 antikoerper, TAF2A antikoerper, XDP antikoerper, TAF(II)250 antikoerper, p250 antikoerper, TBP-associated factor 1 antikoerper, TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa antikoerper, transcription initiation factor TFIID subunit 1 antikoerper, transcription initiation factor TFIID, subunit TAF1 antikoerper, TATA-box binding protein associated factor 1 antikoerper, Taf1 antikoerper, TAF1 antikoerper, LOC5567420 antikoerper, CpipJ_CPIJ003658 antikoerper, TAF11.1 antikoerper, HAF1501 antikoerper, HAF1502 antikoerper, LOC100457071 antikoerper

Hintergrund: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Transcription Initiation Factor TFIID Subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex, which also includes TATA-binding protein (TBP) and a variety of TBP-associated factors.  TFIID nucleates the formation of transcription pre-initiation complexes and plays a key role in the regulation of gene expression by RNA polymerase II.  TAF1 possesses DNA-binding activity and also contains novel N- and C-terminal Ser/Thr kinase domains which can auto-phosphorylate or trans-phosphorylate other transcription factors. For example, TAF1 interacts with the C-terminus of TP53 and phosphorylates the T55 residue, leading to MDM2-mediated degradation of TP53.  TAF1 also catalyzes Ser phosphorylation of general transcription factor IIA (GTF2A1) and IIF (GTF2F1).  The retinoblastoma tumor suppressor protein, RB1, interacts with the N-terminal domain of TAF1 and inhibits its intrinsic kinase activity.  TAF1 is essential for progression through the G1 phase of the cell cycle and has been reported to be indispensable for expression of 18% of mammalian genes.
Synonyms: Transcription Initiation Factor TFIID Subunit 1, TAF1

Gen-ID: 6872, 115942

UniProt: B1Q2X3