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IL1R2 Antikörper (Interleukin 1 Receptor, Type II) (FITC) Primary Antibody

IL1R2 Reaktivität: Human IA, FACS, WB Wirt: Maus Monoclonal 8-5 FITC
Pubmed (2 Referenzen)
Produktnummer ABIN2192219
$692.09
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle IL1R2 Antikörper anzeigen
    IL1R2
    Reaktivität
    • 89
    • 25
    • 18
    Human
    Wirt
    • 61
    • 23
    • 7
    • 1
    Maus
    Klonalität
    • 70
    • 21
    Monoklonal
    Konjugat
    • 48
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL1R2 Antikörper ist konjugiert mit FITC
    Applikation
    • 57
    • 50
    • 26
    • 13
    • 13
    • 8
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunoassay (IA), Flow Cytometry (FACS), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    8-5
  • Applikationshinweise
    It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.02 % sodium azide and 1 % bovine serum albumin.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Müller, Peri, Doni, Perruchoud, Landmann, Pasqualini, Mantovani: "High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration." in: Journal of leukocyte biology, Vol. 72, Issue 4, pp. 643-9, (2002) (PubMed).

    Penton-Rol, Orlando, Polentarutti, Bernasconi, Muzio, Introna, Mantovani et al.: "Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 2931-8, (1999) (PubMed).

  • Target
    IL1R2
    Abstract
    IL1R2 Produkte
    Synonyme
    CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Il1r-2, IL-1R2, interleukin 1 receptor type 2, interleukin 1 receptor, type II, interleukin-like, IL1R2, Il1r2, KK34
    Hintergrund
    And IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. Mouse IgG1
    Pathways
    NF-kappaB Signalweg
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