BRCA2 Antikörper (AA 2480-2530)

Produktnummer ABIN2017604

Produktdetails anti-BRCA2 Antikörper

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Bindungsspezifität: AA 2480-2530

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA2 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Spezifität: BRCA2 Antibody detects endogenous levels of human and mouse BRCA2.

Kreuzreaktivität: Maus

Produktmerkmale: BRCA2 Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 2480-2530 of human BRCA2 (Swiss Prot: P51587).

Aufreinigung: Immunoaffinity chromatography.

Immunogen: KLH-coupled synthetic peptide within residues 2480-2530 of human BRCA2

Isotyp: IgG

Anwendungsinformationen

Kommentare:

Positive Control: HEK293 and Mouse brain

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Konzentration: 0.5 mg/mL

Buffer: Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.

Details zu BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Andere Bezeichnung: BRCA2 (BRCA2 Produkte)

Synonyme: BRCC2 antikoerper, BROVCA2 antikoerper, FACD antikoerper, FAD antikoerper, FAD1 antikoerper, FANCB antikoerper, FANCD antikoerper, FANCD1 antikoerper, GLM3 antikoerper, PNCA2 antikoerper, 30169 antikoerper, BcDNA:SD25109 antikoerper, CG13583 antikoerper, CG13584 antikoerper, CG30169 antikoerper, Dmel\\CG30169 antikoerper, brca2 antikoerper, dmbrca2 antikoerper, fancd1 antikoerper, BRCA2 antikoerper, brcc2 antikoerper, brovca2 antikoerper, facd antikoerper, fad antikoerper, fad1 antikoerper, fancb antikoerper, AI256696 antikoerper, AW045498 antikoerper, Fancd1 antikoerper, RAB163 antikoerper, BRCA2, DNA repair associated antikoerper, Breast cancer 2, early onset homolog antikoerper, breast cancer 2, early onset antikoerper, BRCA2 antikoerper, Brca2 antikoerper, brca2 antikoerper, LOC584780 antikoerper

Hintergrund: Breast cancer type 2 susceptibility protein (BRCA2) is involved in double-strand break repair and/or homologous recombination. It may participate in S phase checkpoint activation. In addition, It interacts with RAD51 and DSS1 and binds to ubiquitinated FANCD2. It also interacts with PALB2, enabling the recombinational repair and checkpoints functions. Defects in BRCA2 can cause genetic susceptibility to breast cancer (BC), also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).

Molekulargewicht: Predicted Band Size: 390 KD
Observed Band Size: 390 KD

UniProt: P51587

Pathways: DNA Reparatur, M Phase, Maintenance of Protein Location