UNC93B1 Antikörper (N-Term)

Produktnummer ABIN1888104

Produktdetails anti-UNC93B1 Antikörper

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNC93B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität (Details): Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide from near the amino terminus of human Unc93b.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu UNC93B1

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Andere Bezeichnung: Unc93b (UNC93B1 Produkte)

Synonyme: UNC93 antikoerper, IIAE1 antikoerper, UNC93B antikoerper, Unc-93B1 antikoerper, Unc93b antikoerper, unc-93 homolog B1, TLR signaling regulator antikoerper, unc-93 homolog B1 (C. elegans) antikoerper, UNC93B1 antikoerper, Unc93b1 antikoerper

Hintergrund: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C.elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling.Unlike Unc93a, another homolog of the C.elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9, the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction.Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
Synonyms: Unc93b1, homolog of C.elegans Unc93

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades