FLIP Antikörper (C-Term, long form)

Produktnummer ABIN1106673

Produktdetails anti-FLIP Antikörper

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Bindungsspezifität: C-Term, long form

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Recognizes FLIP-L No cross reactivity with other proteins.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: A synthetic peptide corresponding to a sequence mapping at the C-terminal of Human FLIP- L, identical to the related Mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 0.2 mL of distilled water to yield a concentration of 0.5 mg/mL.

Konzentration: 0.5 mg/mL

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg Sodium Azide

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody after reconstitution at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FLIP

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Andere Bezeichnung: CFLAR / Casper / I-FLICE (CFLAR Produkte)

Synonyme: Clarp1 antikoerper, cflar antikoerper, CFLAR antikoerper, FLIP antikoerper, CASH antikoerper, CASP8AP1 antikoerper, CLARP antikoerper, Casper antikoerper, FLAME antikoerper, FLAME-1 antikoerper, FLAME1 antikoerper, I-FLICE antikoerper, MRIT antikoerper, c-FLIP antikoerper, c-FLIPL antikoerper, c-FLIPR antikoerper, c-FLIPS antikoerper, 2310024N18Rik antikoerper, A430105C05Rik antikoerper, Cash antikoerper, ENSMUSG00000072980 antikoerper, Flip antikoerper, Gm9845 antikoerper, c-Flip antikoerper, CASP8 and FADD-like apoptosis regulator a antikoerper, CASP8 and FADD like apoptosis regulator antikoerper, CASP8 and FADD like apoptosis regulator S homeolog antikoerper, CASP8 and FADD-like apoptosis regulator antikoerper, cflara antikoerper, CFLAR antikoerper, cflar antikoerper, cflar.S antikoerper, Cflar antikoerper

Hintergrund: Irmler et al. (1997) isolated human cDNAs encoding 2 isoforms of FLIP. FLIP(L), the longer isoform, contains 2 DEDs and a caspase-like domain, and FLIP(S), the shorter isoform, contains only the 2 DEDs followed by a C-terminal extension of approximately 50 amino acids. High levels of FLIP(L) protein were detected in melanoma cell lines and malignant melanoma tumors. FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis.Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP

Gen-ID: 8837

NCBI Accession: NP_001120655

UniProt: O15519

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development