SHP1 Antikörper (AA 553-564)

Produktnummer ABIN1103855

Produktdetails anti-SHP1 Antikörper

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Bindungsspezifität: AA 553-564

Reaktivität: Human, Maus, Ratte, Hamster

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SHP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Marke: IHC-plus™

Spezifität: Mouse PTPN6. This antibody is expected to recognise both reported isoforms (NP_536858.1and NP_002822.2).

Homologie: Percent identity by BLAST analysis: Mouse, Rat, Hamster (100%) Human, Gorilla, Monkey, Marmoset, Panda, Dog, Horse, Pig (92%) Elephant, Opossum (83%).

Aufreinigung: Immunoaffinity purified

Immunogen: Synthetic peptide C-KASRTSSKHKEE from an internal region of mouse PTPN6 (NP_536858.1, NP_002822.2). Percent identity by BLAST analysis: Mouse, Rat, Hamster (100%), Human, Gorilla, Monkey, Marmoset, Panda, Dog, Horse, Pig (92%), Elephant, Opossum (83%).

Type of Immunogen: Synthetic peptide

Anwendungsinformationen

Applikationshinweise: Approved: IHC, IHC-P (5 μg/mL), Peptide-ELISA (1:128000), WB (0.1 - 0.3 μg/mL)

Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 60-70 kDa band observed in Human Bone Marrow and Liver lysates (calculated MW of 67.6 kDa according to NP_536858.1and NP_002822.2). Recommended concentration: 0.1-0.3 μg/mL.Tested in IHC-P using FFPE human tissues, has not been tested in IHC with mouse samples.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Details zu SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Andere Bezeichnung: PTPN6 / SHP-1 (PTPN6 Produkte)

Synonyme: HCPH antikoerper, HPTP1C antikoerper, PTP-1C antikoerper, SH-PTP1 antikoerper, SHP-1 antikoerper, SHP-1L antikoerper, SHP1 antikoerper, DRPLA antikoerper, Hcph antikoerper, Ptp1C antikoerper, me antikoerper, motheaten antikoerper, Ptph6 antikoerper, Shp-1 antikoerper, fj22f05 antikoerper, wu:fj22f05 antikoerper, zgc:55501 antikoerper, ptpn6 antikoerper, protein tyrosine phosphatase, non-receptor type 6 antikoerper, protein tyrosine phosphatase, non-receptor type 6 L homeolog antikoerper, PTPN6 antikoerper, Ptpn6 antikoerper, ptpn6 antikoerper, ptpn6.L antikoerper

Hintergrund: Name/Gene ID: PTPN6
Subfamily: NT2
Family: Protein Phosphatase

Synonyms: PTPN6, HCP, HPTP1C, Hematopoietic cell phosphatase, PTP-1C, SH-PTP1, SHP-1L, SHP-1, Shptp1, HCPH, PTP1C, SHP1

Gen-ID: 5777

NCBI Accession: NP_536858, NP_002822

UniProt: P29350

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling