anti-UV Radiation Resistance Associated Gene (UVRAG) Antikörper

UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. Zusätzlich bieten wir Ihnen UVRAG Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
UVRAG 7405 Q9P2Y5
UVRAG 78610  
UVRAG 308846  
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB Immunoprecipitation and western blot analysis of anti-UVRAG Pab (ABIN388586) in 293T cells. UVRAG is immunoprecipitated (Lane 2) and detected in 293T cell transiently transfected with mouse UVRAG (Lane 1). Detection of endogenous UVRAG is shown in 293T cells (Lane 3) but is reduced by UVRAG siRNA transfection (Lane 4). Data courtesy of Dr. Hong-Gang Wang, Moffitt Cancer Center, Tampa, FL. Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388586) on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki,Finland. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
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Human Kaninchen Unkonjugiert IF, IHC (p), WB Western blot analysis of anti-hUVRAG (Center) Pab (ABIN388588) in mouse liver tissue lysate. hUVRAG (Center)(arrow) was detected using the purified polyclonal antibody. Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388588) on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki,Finland. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-hUVRAG (Center) Pab (ABIN388587) in mouse heart tissue lysates. hUVRAG (Center)(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG (Center) (ABIN388587), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
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Hamster Maus Unkonjugiert IP, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$313.50
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Human Kaninchen Unkonjugiert EIA, IF, IHC (p), IP, WB   0.4 mL Anmelden zum Anzeigen 12 bis 15 Tage
$518.65
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Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: UVRAG Antibody [NBP1-18885] - FFPE section of mouse renal cell carcinoma. Affinity purified rabbit anti-UVRAG used at a dilution of 1:250. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
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Human Maus Unkonjugiert IF, ELISA, WB Detection limit for recombinant GST tagged UVRAG is 0.3 ng/ml as a capture antibody. Western Blot analysis of UVRAG expression in transfected 293T cell line by UVRAG monoclonal antibody (M04), clone 2E8.<br><br>Lane 1: UVRAG transfected lysate (Predicted MW: 78.2 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen HRP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-UVRAG Polyclonal Antibody . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-UVRAG Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Late Endosome, Lysosome, Early Endosome. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) UVRAG Antibody (D) Composite. Western blot analysis of Human 293T showing detection of ~70kDa UVRAG protein using Rabbit Anti-UVRAG Polyclonal Antibody . Lane 1: MW Ladder. Lane 2: Human 293T (20 µg). Load: 20 µg. Block: 5% milk + TBST for 1 hour at RT. Primary Antibody: Rabbit Anti-UVRAG Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit: HRP at 1:2000 for 1 hour at RT. Color Development: TMB solution for 12 min at RT. Predicted/Observed Size: ~70kDa. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$487.03
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Human Kaninchen FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-UVRAG Polyclonal Antibody . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-UVRAG Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Late Endosome, Lysosome, Early Endosome. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) UVRAG Antibody (D) Composite. Western blot analysis of Human 293T showing detection of ~70kDa UVRAG protein using Rabbit Anti-UVRAG Polyclonal Antibody . Lane 1: MW Ladder. Lane 2: Human 293T (20 µg). Load: 20 µg. Block: 5% milk + TBST for 1 hour at RT. Primary Antibody: Rabbit Anti-UVRAG Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit: HRP at 1:2000 for 1 hour at RT. Color Development: TMB solution for 12 min at RT. Predicted/Observed Size: ~70kDa. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$492.09
Details
Human Kaninchen Alkaline Phosphatase (AP) ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-UVRAG Polyclonal Antibody . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-UVRAG Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Late Endosome, Lysosome, Early Endosome. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) UVRAG Antibody (D) Composite. Western blot analysis of Human 293T showing detection of ~70kDa UVRAG protein using Rabbit Anti-UVRAG Polyclonal Antibody . Lane 1: MW Ladder. Lane 2: Human 293T (20 µg). Load: 20 µg. Block: 5% milk + TBST for 1 hour at RT. Primary Antibody: Rabbit Anti-UVRAG Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit: HRP at 1:2000 for 1 hour at RT. Color Development: TMB solution for 12 min at RT. Predicted/Observed Size: ~70kDa. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$494.62
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UVRAG Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-UVRAG Antikörper

  1. Human Polyclonal UVRAG Primary Antibody für IF, IHC (p) - ABIN388586 : Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. in Nature cell biology 2006 (PubMed)
    Show all 10 Pubmed References

  2. Human Polyclonal UVRAG Primary Antibody für WB - ABIN1882151 : Vogt, Affara, Davey, Hammer, Jobling, Lau, Mitchell, Schempp, Tyler-Smith, Williams, Yen, Rappold: Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. in Cytogenetics and cell genetics 1998 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal UVRAG Primary Antibody für ICC, IF - ABIN438721 : Sun, Li, Zhang, Chen, Zhang, Li, Deng, Qian, Jiao, Ji, Li, Wu, Yu, Feng, Zhu: Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. in Nature communications 2015 (PubMed)

Weitere Antikörper gegen UVRAG Interaktionspartner

Human UV Radiation Resistance Associated Gene (UVRAG) Interaktionspartner

  1. Our findings suggest that up-regulation of UVRAG by HDAC1 (zeige HDAC1 Antikörper) inhibition potentiates DNA-damage-mediated cell death in colorectal cancer cells

  2. UVRAG plays an essential role in protecting cells from UV-induced DNA damage by activating the nucleotide excision repair pathway

  3. UVRAG is a regulator of CRL4(DDB2 (zeige DDB2 Antikörper))-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition.

  4. Under-expression of UVRAG is associated with colorectal cancer.

  5. UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect.

  6. HCV, by differentially inducing the expression of Rubicon (zeige KIAA0226 Antikörper) and UVRAG, temporally regulated the autophagic flux to enhance its replication.

  7. tubulation requires mTOR (zeige FRAP1 Antikörper) activity, and we identified two direct mTOR (zeige FRAP1 Antikörper) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (zeige PIK3C3 Antikörper).

  8. Beclin 1 (zeige BECN1 Antikörper) and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells.

  9. Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR (zeige EGFR Antikörper)), reduces EGFR (zeige EGFR Antikörper) signaling, and suppresses cancer cell proliferation and tumor growth.

  10. The reports that Grb2 (zeige GRB2 Antikörper), when in excess (zeige RCC1 Antikörper), interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 (zeige GRB2 Antikörper) or Grb2 (zeige GRB2 Antikörper).

Mouse (Murine) UV Radiation Resistance Associated Gene (UVRAG) Interaktionspartner

  1. UVRAG is a regulator of CRL4(DDB2 (zeige DDB2 Antikörper))-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition.

  2. Beclin 1 (zeige BECN1 Antikörper) regulates endosome pathways via the UVRAG-VPS34 (zeige PIK3C3 Antikörper) complex.

  3. EWSR1 (zeige EWSR1 Antikörper) is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  4. tubulation requires mTOR (zeige FRAP1 Antikörper) activity, and we identified two direct mTOR (zeige FRAP1 Antikörper) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (zeige PIK3C3 Antikörper).

  5. silencing of UVRAG significantly attenuated the antimicrobial effects of macrophages against M. tuberculosis.

  6. data provide novel insights into the control of autophagy in T cells and identify UVRAG as a new regulator of naive peripheral T-cell homeostasis.

  7. in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (zeige SLAMF1 Antikörper) interacts with the class III PI3K Vps34 (zeige PIK3C3 Antikörper) in a complex with Beclin-1 (zeige BECN1 Antikörper) and UVRAG

  8. UVRAG has cytoprotective functions in the cytosol that control the localization of Bax (zeige BAX Antikörper) in tumor cells exposed to apoptotic stimuli

  9. through ultraviolet irradiation resistance-associated gene (UVRAG), Bif-1 (zeige SH3GLB1 Antikörper) interacts with Beclin 1 (zeige BECN1 Antikörper) and functions as a positive mediator of the class III PI(3 (zeige PI3 Antikörper)) kinase (PI(3 (zeige PI3 Antikörper))KC3).

  10. These results suggest that mammalian cells have at least two distinct class III PI3-kinase (zeige PIK3CA Antikörper) complexes, and that beclin 1 (zeige BECN1 Antikörper) interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes.

Fruit Fly (Drosophila melanogaster) UV Radiation Resistance Associated Gene (UVRAG) Interaktionspartner

  1. The UVRAG-containing PI3K (III) complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing.

  2. UVRAG-mutated heterotaxy patient cells also display highly increased Notch (zeige NOTCH1 Antikörper) protein levels

UVRAG Antigen-Profil

Protein Überblick

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Genbezeichner und Symbole assoziert mit UVRAG

  • UV radiation resistance associated (UVRAG) Antikörper
  • UV radiation resistance associated gene (Uvrag) Antikörper
  • UV radiation resistance associated gene (uvrag) Antikörper
  • UV radiation resistance associated (Uvrag) Antikörper
  • UV radiation resistance associated S homeolog (uvrag.S) Antikörper
  • UV radiation resistance associated L homeolog (uvrag.L) Antikörper
  • UV radiation resistance associated (uvrag) Antikörper
  • UV-resistance associated gene (Uvrag) Antikörper
  • 9530039D02Rik Antikörper
  • AI648770 Antikörper
  • BB124205 Antikörper
  • CG6116 Antikörper
  • DHTX Antikörper
  • Dmel\\CG6116 Antikörper
  • MGC81810 Antikörper
  • MGC131135 Antikörper
  • p63 Antikörper
  • UVRAG Antikörper
  • Uvrag1 Antikörper
  • Uvragl Antikörper
  • VPS38 Antikörper
  • zgc:56164 Antikörper

Bezeichner auf Proteinebene für UVRAG

UV radiation resistance-associated gene protein , beclin 1 binding protein , disrupted in heterotaxy , UV radiation resistance associated , UV radiation resistance associated gene , UV radiation resistance-associated gene protein-like , CG6116-PA , CG6116-PB , Uvrag-PA , Uvrag-PB

GENE ID SPEZIES
7405 Homo sapiens
607998 Canis lupus familiaris
451430 Pan troglodytes
78610 Mus musculus
394044 Danio rerio
308846 Rattus norvegicus
779151 Xenopus laevis
419091 Gallus gallus
614285 Bos taurus
696601 Macaca mulatta
735238 Xenopus laevis
100413829 Callithrix jacchus
100477039 Ailuropoda melanoleuca
100486296 Xenopus (Silurana) tropicalis
100544950 Meleagris gallopavo
100552937 Anolis carolinensis
100595542 Nomascus leucogenys
100051722 Equus caballus
100354086 Oryctolagus cuniculus
100443180 Pongo abelii
34735 Drosophila melanogaster
100718392 Cavia porcellus
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