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STK10 encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Zusätzlich bieten wir Ihnen Serine/Threonine Kinase 10 Antikörper (92) und und viele weitere Produktgruppen zu diesem Protein an.
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Binding of phosphatidylinositol 4,5-biphosphate to ezrin (zeige EZR Proteine) induces a conformational change permitting the insertion of the LOK C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin (zeige EZR Proteine). The N-terminal LOK kinase domain can then access a site 40 residues distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue.
The gene signature of OPA1 (zeige OPA1 Proteine), CTSA (zeige CTSA Proteine), NDUFA1 (zeige NDUFA1 Proteine), STK10 and PRDX1 (zeige PRDX1 Proteine) was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.
STK10 functions as a tumor suppressor gene, and dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis.
It was shown that lymphocyte-oriented and STE20 kinase (zeige SLK Proteine) were sufficient to restrict ezrin (zeige EZR Proteine) function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
Opposing roles of serine/threonine kinases MEKK1 (zeige MAP3K1 Proteine) and LOK in regulating the CD28 (zeige CD28 Proteine) responsive element in T-cells
Stk10 is a novel polo-like kinase kinase that cooperates with hSlk to regulate Plk1 function in human cells
These studies identify a new ERM (zeige ETV5 Proteine) kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin (zeige MSN Proteine) phosphorylation in regulating cell shape and motility.
kinases, including Slk (zeige SLK Proteine), Lok and Mst1 (zeige MST1 Proteine), are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
, serine/threonine-protein kinase 10
, polo-like kinase kinase 1
, serine/threonine-protein kinase 10-A
, germ cell kinase 1