STK10-A Protein (His tag)

Produktnummer ABIN7317065

Produktdetails

Target: STK10-A (Serine/threonine Kinase 10 (STK10-A))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses STK10-A Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human STK10/LOK Protein (His Tag)(Active)

Sequenz: Arg 18-Glu 317

Produktmerkmale: A DNA sequence encoding the human STK10 (NP_005981.3) (Arg 18-Glu 317) was expressed, with a polyhistide tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Biological Activity Comment: The specific activity was determined to be 1353 nmol/min/mg using synthetic AXLtide peptide (KKSRGDYMTMQIG) as substrate.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.0

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: STK10-A (Serine/threonine Kinase 10 (STK10-A))

Andere Bezeichnung: STK10/LOK (STK10-A Produkte)

Synonyme: LOK Protein, PRO2729 Protein, Gek1 Protein, Lok Protein, mKIAA4026 Protein, zgc:63495 Protein, plkk1 Protein, stk10 Protein, xPlkk1 Protein, serine/threonine kinase 10 Protein, serine/threonine kinase 10 S homeolog Protein, STK10 Protein, Stk10 Protein, stk10 Protein, stk10.S Protein

Hintergrund:

Background: Serine / threonine-protein kinase 10, also known as Lymphocyte-oriented kinase, STK10 and LOK, which belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE20 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste20 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK10 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK10 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk10 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.

Synonym: LOK;PRO2729

Molekulargewicht: 36 kDa

NCBI Accession: NP_005981