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This locus encodes an inositol monophosphatase. Zusätzlich bieten wir Ihnen IMPA2 Antikörper (25) und IMPA2 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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IMPA2 has a separate function in vivo from that of IMPA1
IMPA2 is a protein-coding gene for a catalytic protein that converts inositol monophosphate into free inositol through dephosphorylation.
a correlation between an IMPA2 polymorphism rs589247 and ischemic stroke risk in a northwest Han Chinese
a promoter polymorphism of IMPA2 possibly contributed to risk for schizophrenia by elevating transcription activity in Han Chinese individuals.
results suggest that genetic variability at rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and rs11921360-GSK3b genes is associated with a higher risk of attempting suicide in bipolar patients.
Authors propose that the human myo-inositol monophosphatase 2 interacts with myo-inositol monophosphates in the three-metal-ion bound form, and proceeds the dephosphorylation through the three-metal-ion theory.
No association is found between IMPA2 gene polymorphisms and bipolar disorder.
The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.
Promoter is polymorphic in bipolar disorder.
IMPA2 may be a febrile seizure susceptibility gene. 6 SNPs were found: -708G/A, -461C/T, IVS1-15G/A, 159T/C, IVS5+13-14insA, & 558C/T.
the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations.
The crystal structures of human IMPA2 are useful for understanding the effect of nonsynonymous polymorphism reported in IMPA2, and will contribute to further functional analyses of IMPA2.
data suggest that the genetic variants in the IMPA2 gene are not associated with a risk of febrile seizures in Caucasian patients and patients from various genetic groups are likely to have different genetic causes of febrile seizures
Single nucleotide polymorphism in IMPA2 gene is associated with acute lymphoblastic leukemia.
The product of this gene has been functionally characterized as the U7 snRNP-associated Sm-like protein Lsm11
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder.
inositol(myo)-1(or 4)-monophosphatase 2
, inositol monophosphatase 2
, IMP 2
, IMPase 2
, inositol-1(or 4)-monophosphatase 2
, myo-inositol monophosphatase A2
, inosine monophosphatase 2
, inositol monophosphatase 2 variant 1
, inositol monophosphatase 2 variant 2