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IMPA1 encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. Zusätzlich bieten wir Ihnen Inositol(myo)-1(or 4)-Monophosphatase 1 Antikörper (37) und Inositol(myo)-1(or 4)-Monophosphatase 1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.
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IMPase has a role in intracellular myo (zeige SYNPO2 Proteine)-inositol synthesis in craniofacial development and the maintenance of proper brain function
local synthesis of IMPA1 is required for neurotrophin (zeige BDNF Proteine)-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases
IMPA1 was expressed in round spermatids
Results suggest that calbindin D28k (zeige CALB1 Proteine) acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo (zeige SYNPO2 Proteine)-inositol monophosphatase in central neurons.
IMPA2 (zeige IMPA2 Proteine) has a separate function in vivo from that of IMPA1
IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium
Multibody magnesium cofactor and myo (zeige SYNPO2 Proteine)-inositol substrate molecular recognition in the myo (zeige SYNPO2 Proteine)-inositol monophosphatase enzyme have been described.
The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior.
The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 (zeige IMPA2 Proteine) transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
inositol monophosphatase 1
, Inositol monophosphatase
, IMP 1
, IMPase 1
, inositol-1(or 4)-monophosphatase 1
, lithium-sensitive myo-inositol monophosphatase A1
, myo-inositol monophosphatase