Inositol(myo)-1(or 4)-Monophosphatase 1 Proteine (IMPA1)

IMPA1 encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. Zusätzlich bieten wir Ihnen Inositol(myo)-1(or 4)-Monophosphatase 1 Antikörper (38) und Inositol(myo)-1(or 4)-Monophosphatase 1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IMPA1 55980  
IMPA1 83523 P97697
IMPA1 3612 P29218
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Top Inositol(myo)-1(or 4)-Monophosphatase 1 Proteine auf antikoerper-online.de

Showing 10 out of 18 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 4 bis 8 Tage
$504.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$437.80
Details
Hefe Mesembryanthemum crystallinum His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,704.17
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,724.33
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,724.33
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,724.33
Details

IMPA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human , , ,
, ,

Weitere Proteine zu Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Interaktionspartnern

Mouse (Murine) Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Interaktionspartner

  1. Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior

  2. IMPase has a role in intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function

  3. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A

  4. local synthesis of IMPA1 is required for neurotrophin-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases

  5. IMPA1 was expressed in round spermatids

  6. Results suggest that calbindin D28k acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo-inositol monophosphatase in central neurons.

  7. IMPA2 has a separate function in vivo from that of IMPA1

  8. IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium

Human Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Interaktionspartner

  1. the high-resolution X-ray structure of human IMPase in complex with L690,330 and manganese ions determined at 1.39 A resolution is reported.

  2. Multibody magnesium cofactor and myo-inositol substrate molecular recognition in the myo-inositol monophosphatase enzyme have been described.

  3. The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior.

  4. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A

  5. The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.

  6. No association between polymorphisms and bipolar disorder

  7. IMPA2 has a separate function in vivo from that of IMPA1

Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Protein Überblick

Protein Überblick

This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Genbezeichner und Symbole assoziert mit IMPA1

  • inositol monophosphatase 1 (impa1)
  • inositol(myo)-1(or 4)-monophosphatase 1 (impa1)
  • inositol (myo)-1(or 4)-monophosphatase 1 (Impa1)
  • inositol monophosphatase 1 (Impa1)
  • inositol monophosphatase (impa1)
  • inositol monophosphatase 1 (IMPA1)
  • inositol(myo)-1(or 4)-monophosphatase 1 S homeolog (impa1.S)
  • inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1)
  • 2610002K09Rik Protein
  • 2900059K10Rik Protein
  • AI325909 Protein
  • IMP Protein
  • impa Protein
  • zgc:100926 Protein

Bezeichner auf Proteinebene für IMPA1

inositol monophosphatase 1 , Inositol monophosphatase , IMP 1 , IMPase 1 , inositol-1(or 4)-monophosphatase 1 , lithium-sensitive myo-inositol monophosphatase A1 , myo-inositol monophosphatase

GENE ID SPEZIES
437018 Danio rerio
100301752 Oncorhynchus mykiss
100380569 Salmo salar
55980 Mus musculus
83523 Rattus norvegicus
397905 Xenopus laevis
3612 Homo sapiens
444552 Xenopus laevis
477925 Canis lupus familiaris
397425 Sus scrofa
281865 Bos taurus
100174641 Pongo abelii
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