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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation.
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Mammalian Monoclonal TRDMT1 Primary Antibody für ISt, IHC - ABIN1304620
Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014
Human Polyclonal TRDMT1 Primary Antibody für IHC (p), WB - ABIN4305755
Bonnin, Belville, Chiambaretta, Sapin, Blanchon: DNA methyl transferases are differentially expressed in the human anterior eye segment. in Acta ophthalmologica 2014
Human Polyclonal TRDMT1 Primary Antibody für IHC (p), WB - ABIN387892
Chedin, Lieber, Hsieh: The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 3 Pubmed References
Human Polyclonal TRDMT1 Primary Antibody für WB - ABIN2668677
Ajj, Chesnel, Pinel, Plenat, Flament, Dumond: An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. in PLoS ONE 2013
The Sirt1 (zeige SIRT1 Antikörper) protein suppressed transcription of Dnmt3l.
The Dnmt3l mutation greatly reduced DNA methylation (zeige HELLS Antikörper) levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 (zeige PLD6 Antikörper) mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation (zeige HELLS Antikörper), many showed increased expression at the RNA level.
Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming
By interacting with TRIM28 (zeige TRIM28 Antikörper), DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins.
Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a (zeige DNMT3A Antikörper) due to hepatitis B X-protein bound to their promoters.
DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells
Study demonstrates that Dnmt3L interacts with the Polycomb (zeige CBX2 Antikörper) PRC2 complex in competition with the DNA methyltransferases Dnmt3a (zeige DNMT3A Antikörper) and Dnmt3b (zeige DNMT3B Antikörper) to maintain low methylation levels at the Histone 3 H3K27me3 regions.
Data indicate that expression of Dnmt3a (zeige DNMT3A Antikörper), Dnmt3b (zeige DNMT3B Antikörper), Dnmt3L as well as maintenance Dnmt1o (zeige DNMT1 Antikörper) in oocytes and zygotes was not disrupted.
Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells.
The maternal store of Dnmt3L is not involved in embryonic de novo methylation.
DNMT3L overexpression is associated with Down syndrome.
the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.
DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.
crystal structures of DNMT3A (zeige DNMT3A Antikörper)-DNMT3L (autoinhibitory form) and DNMT3A (zeige DNMT3A Antikörper)-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively
DNMT3L can address DNMT3A (zeige DNMT3A Antikörper)/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A (zeige DNMT3A Antikörper)/B
CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX (zeige VAC14 Antikörper) response element
DNMT3L is one of the key players in de novo DNA methylation (zeige HELLS Antikörper) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)
SNP rs2070565, as well as haplotypes AAA (zeige APP Antikörper) and GAA (zeige GAA Antikörper), may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans
Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.
mutation analysis of SYCP3 (zeige SYCP3 Antikörper), DNMT3L and MSH4 (zeige MSH4 Antikörper) in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5-)-methyltransferase 3-like
, cytosine-5-methyltransferase 3-like protein
, DNA (cytosine-5)-methyltransferase 3-like
, human cytosine-5-methyltransferase 3-like protein