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The protein encoded by CDC27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2.
Showing 4 out of 4 products:
Cdc27 directs cyclin D1 (zeige CCND1 Antikörper) to alternative degradation by anaphase promoting complex/cyclosome.
mir (zeige MLXIP Antikörper)-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 expression.
The levels of CDC20 (zeige CDC20 Antikörper) and CylinB1 increased and the levels of Ku70 (zeige XRCC6 Antikörper) and APC3 decreased after irradiation. APC (zeige APC Antikörper)/C(Cdh1 (zeige CDH1 Antikörper)) is involved in regulation of radiosensitivity in human NPC (zeige NPC1 Antikörper) CNE-1 cells.
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
Cdc27 is a novel binding partner of Elmo1 (zeige ELMO1 Antikörper).Cdc27-Elmo1 (zeige ELMO1 Antikörper) has a cellular role independent from the Elmo-Dock1 (zeige DOCK1 Antikörper)-Rac (zeige AKT1 Antikörper) signal module.
miR (zeige MLXIP Antikörper)-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR (zeige MLXIP Antikörper)-27a and its downregulation conferred increased radioresistance of the cells.
These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
The structures show how one APC16 (zeige ANAPC16 Antikörper) binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 (zeige ANAPC16 Antikörper) recruits APC7 (zeige ANAPC7 Antikörper) to APC3.
Low cdc27 and high securin (zeige PTTG1 Antikörper) expression predict short survival for breast cancer patients.
Down-regulation of CDC27 protein is associated with radiation resistance.
Data indicate that additional density present in the anaphase-promoting complex (APC (zeige APC Antikörper)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7 (zeige ANAPC7 Antikörper), a subunit specific to vertebrate APC (zeige APC Antikörper)/C.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell division cycle 27 homolog
, cell division cycle protein 27 homolog
, cell division cycle protein 27
, CDC27 homolog
, anaphase promoting complex subunit 3
, anaphase-promoting complex subunit 3
, anaphase-promoting complex, protein 3
, nuc2 homolog