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ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.
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Cow (Bovine) Polyclonal ADAMTS4 Primary Antibody für IHC, WB - ABIN2776877
Lee, Hwang, Park, Lee, Park, Kang, Lee, Kim, Park, Park: Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. in Journal of clinical pathology 2011
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Human Polyclonal ADAMTS4 Primary Antibody für WB - ABIN391642
Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000
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This study demonstrated that ADAMTS-4 is a new marker of mature oligodendrocytes contributing to the myelination processes and thus to the control of motor capacities.
results demonstrate for the first time that ADAMTS4 contributes to diet induced atherosclerosis in ApoE (zeige APOE Antikörper)(-/-) mice
the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues
Results show that ADAMTS15 (zeige ADAMTS15 Antikörper) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
aggrecan (zeige ACAN Antikörper) and brevican (zeige BCAN Antikörper) proteolysis is compensated in Adamts4-/- or Adamts5 (zeige ADAMTS5 Antikörper)-/- mice by ADAMTS (zeige ADAMTS1 Antikörper) proteoglycanase (zeige MMP3 Antikörper) family members but a threshold of versican (zeige Vcan Antikörper) proteolysis is sensitive to the loss of a single ADAMTS (zeige ADAMTS1 Antikörper) proteoglycanase (zeige MMP3 Antikörper) during spinal cord injury
ADAMTS4 has roles in melanoma growth and angiogenesis in mice
The serine protease (zeige F2 Antikörper) tissue plasminogen activator (tPA (zeige PLAT Antikörper)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (zeige ADAMTS5 Antikörper), were identified as Reelin (zeige RELN Antikörper) cleaving enzymes.
ADAMTS-4 cleaves Reelin (zeige RELN Antikörper) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (zeige LSP1 Antikörper) cleaves the N-t site only, while p75 (zeige NGFR Antikörper) cleaves both sites.
Data demonstrate that Adamts1 (zeige ADAMTS1 Antikörper) and Adamts4 play redundant and essential roles in perinatal kidney development.
Drastic down-regulation of Adamts4 observed at both E16 (zeige SLC7A5 Antikörper) and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.
ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC (zeige CALR Antikörper) and ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo.
ADAMTS4 expression was upregulated during carotid atherosclerotic plaque development. Serum levels of ADAMTS4 were associated with increased plaque vulnerability in both symptomatic and asymptomatic patients with carotid artery stenosis.
methylation status of the ADAMTS4 gene is altered in patellar tendinopathy
HipHop-based pharmacophore modeling and virtual screening of the Maybridge database to identify novel ADAMTS-4 inhibitors. These novel lead compounds act as potent and specific inhibitors for the ADAMTS-4 enzyme and could have therapeutic potential in the treatment of OA.
ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.
Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 (zeige FBLN2 Antikörper) is a better substrate for ADAMTS-5 (zeige ADAMTS5 Antikörper) than it is for ADAMTS-4. Fibulin-2 (zeige FBLN2 Antikörper) degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.
ADAMTS4 and ADAMTS15 (zeige ADAMTS15 Antikörper) were upregulated in symptomatic uterine leiomyomas.
The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.
Single Nucleotide Variants of Candidate Genes in Aggrecan (zeige ACAN Antikörper) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
Results show that ADAMTS4 mRNA is the target of mir (zeige MLXIP Antikörper)-1268a and its expression might be modified by MIR (zeige MLXIP Antikörper)-1268a rs28599926 polymorphism in hepatocellular carcinoma.
ADAMTS4 participates in the regulation of muscle development in cattle.
aggrecanase activity (a) is responsible for early TNFalpha (zeige TNF Antikörper)-dependent aggrecan (zeige ACAN Antikörper) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
ADAMTS4 and ADAMTS5 (zeige ADAMTS5 Antikörper) are inhibited by alpha2-macroglobulin (zeige A2M Antikörper)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (zeige ADAMTS5 Antikörper)
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
A disintegrin and metalloproteinase with thrombospondin motifs 4
, ADAM-TS 4
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
, a disintegrin and metallopeptidase with thrombospondin motifs 4
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
, ADAM metallopeptidase with thrombospondin type 1 motif, 4
, A disintegrin and metalloproteinase with thrombospondin motifs 4-like
, disintegrin and metalloproteinase with thrombospondin motifs 2
, a disintegrin and metalloproteinase with thrombospondin motifs 4