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RAF1 Antikörper (Middle Region)
RAF1
Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd, Zebrafisch (Danio rerio), Meerschweinchen
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2792055
Produktdetails anti-RAF1 Antikörper
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Target
Alle RAF1 Antikörper anzeigen
RAF1
(V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
Bindungsspezifität
Alle Epitope für RAF1 Antikörper
Middle Region
Reaktivität
Alle Reaktivitäten für RAF1 Antikörper
Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd, Zebrafisch (Danio rerio), Meerschweinchen
Wirt
Alle Wirte für RAF1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für RAF1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für RAF1 Antikörper
Dieser RAF1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für RAF1 Antikörper
Western Blotting (WB)
Sequenz
SGTQEKNKIR PRGQRDSSYY WEIEASEVML STRIGSGSFG TVYKGKWHGD
Homologie
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
Produktmerkmale
This is a rabbit polyclonal antibody against RAF1. It was validated on Western Blot.
Aufreinigung
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human RAF1
Top Product
Discover our top product RAF1 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeat freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu RAF1
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Target
RAF1
(V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
Andere Bezeichnung
RAF1 (RAF1 Produkte )
Synonyme
CRAF antikoerper, NS5 antikoerper, Raf-1 antikoerper, c-Raf antikoerper, c-raf antikoerper, craf antikoerper, raf1 antikoerper, RAF1 antikoerper, 6430402F14Rik antikoerper, AA990557 antikoerper, BB129353 antikoerper, Craf1 antikoerper, D830050J10Rik antikoerper, v-Raf antikoerper, raf antikoerper, cRaf antikoerper, Raf-1 proto-oncogene, serine/threonine kinase antikoerper, Raf-1 proto-oncogene, serine/threonine kinase a antikoerper, v-raf-leukemia viral oncogene 1 antikoerper, Raf-1 proto-oncogene, serine/threonine kinase S homeolog antikoerper, RAF1 antikoerper, Raf1 antikoerper, raf1a antikoerper, raf1 antikoerper, raf1.S antikoerper
Hintergrund
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. Protein Interaction Partner: Prkab1, FYCO1, NPLOC4, TMEM70, COPS7A, DCAF8, PACSIN3, YWHAQ, RANBP9, RB1, PURA, MAP2K2, MAP2K1, MAPK3, MAPK1, PRKAR1A, MYBPC1, HSP90AA1, AKT1, FAM96B, MRAS, HUWE1, SHOC2, UBC, CDC37, IRS4, GPRASP2, STUB1, SH3KBP1, HIPK4, CDK20, YWHAB, TBXA2R, KRAS, YWHAE Protein Size: 567
Molekulargewicht
62 kDa
Gen-ID
5894
NCBI Accession
XP_005265415
UniProt
B4E0X2
Pathways
MAPK Signalweg , RTK Signalweg , Fc-epsilon Rezeptor Signalübertragung , Neurotrophin Signalübertragung , cAMP Metabolic Process , Stem Cell Maintenance , Hepatitis C , Autophagie , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling , BCR Signaling
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