C-JUN Antikörper (N-Term)
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- Target Alle C-JUN (JUN) Antikörper anzeigen
- C-JUN (JUN) (Jun Proto-Oncogene (JUN))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser C-JUN Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL
- Kreuzreaktivität
- Rind (Kuh), Hund, Human, Maus, Ratte (Rattus)
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 92%
- Produktmerkmale
- This is a rabbit polyclonal antibody against JUNB. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human JUNB
- Top Product
- Discover our top product JUN Primärantikörper
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- Applikationshinweise
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WB Suggested Anti-JUNB Antibody Titration: 1.25 µg/mL
ELISA Titer: 1:1562500
Positive Control: Transfected 293T.
Optimal working dilutions should be determined experimentally by the investigator. - Kommentare
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Antigen size: 347 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- C-JUN (JUN) (Jun Proto-Oncogene (JUN))
- Andere Bezeichnung
- Jun (JUN Produkte)
- Synonyme
- AP-1 antikoerper, AP1 antikoerper, c-Jun antikoerper, fj36h07 antikoerper, wu:fj36h07 antikoerper, zgc:65863 antikoerper, Junc antikoerper, c-jun antikoerper, CG2275 antikoerper, D-Jun antikoerper, D-jun antikoerper, D-jun/Jra antikoerper, DJUN antikoerper, DJun antikoerper, Djun antikoerper, Dmel\\CG2275 antikoerper, JRA antikoerper, JUN antikoerper, Jun antikoerper, V antikoerper, cJun antikoerper, d-JRA antikoerper, d-Jun antikoerper, d-jun antikoerper, dAP-1 antikoerper, dJRA antikoerper, dJUN antikoerper, dJra antikoerper, dJun antikoerper, djun antikoerper, dm-Jun antikoerper, jra antikoerper, jun antikoerper, l(2)46Ef antikoerper, l(2)IA109 antikoerper, l(2R)IA109 antikoerper, Jun proto-oncogene, AP-1 transcription factor subunit antikoerper, jun proto-oncogene S homeolog antikoerper, jun proto-oncogene antikoerper, Jun-related antigen antikoerper, jun proto-oncogene L homeolog antikoerper, JUN antikoerper, Jun antikoerper, jun.S antikoerper, jun antikoerper, Jra antikoerper, jun.L antikoerper
- Hintergrund
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The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.
Alias Symbols: AP-1
Protein Interaction Partner: BATF, FOS, RFWD2, C19orf68, USP24, TCERG1, ZNF595, PKIA, MAP2, APLP2, FOSL1, DDIT3, ATF3, BATF2, BATF3, TCL1A, FOSL2, NPM1, NEU1, SMAD4, HOXA7, BDNF, ATF4, MAPK6, UBC, TDG, SET, SAT1, MAPK9, BRCA1, SUMO2, Cebpb, EP300, SMURF1, YY1, CREBBP, SMARCA4, JDP2,
Protein Size: 347 - Molekulargewicht
- 36 kDa
- Gen-ID
- 3726
- NCBI Accession
- NM_002229, NP_002220
- UniProt
- P17275
- Pathways
- MAPK Signalweg, RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteine
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