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RIPK1 Antikörper

RIPK1 Reaktivität: Human, Maus, Ratte WB, IP, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN127073
  • Target Alle RIPK1 Antikörper anzeigen
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Reaktivität
    • 88
    • 41
    • 30
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 81
    • 14
    Kaninchen
    Klonalität
    • 73
    • 22
    Polyklonal
    Konjugat
    • 39
    • 9
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RIPK1 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 33
    • 22
    • 15
    • 15
    • 13
    • 13
    • 11
    • 6
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    The antibody detects 74 kDa RIP in Western blot analysis.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse and Rat.
    Aufreinigung
    Affinity Chromatography.
    Immunogen
    Synthetic peptide surrounding amino acid 645 of Human RIP
    Top Product
    Discover our top product RIPK1 Primärantikörper
  • Applikationshinweise
    Western Blot: 2-6 μg/mL. Immunoprecipitation. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    PBS, pH 7.2, containing 30 % Glycerol, 0.5 % BSA as stabilizer and 0.01 % Thimerosal as preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store the antibody undiluted at -20 °C or (in aliquots) at -70 °C for long term storage.
  • Target
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Andere Bezeichnung
    RIP (RIPK1 Produkte)
    Synonyme
    RIP antikoerper, RIP1 antikoerper, D330015H01Rik antikoerper, Rinp antikoerper, Rip1 antikoerper, rip1 antikoerper, ripk1 antikoerper, xRIP1beta antikoerper, xrip1 antikoerper, receptor interacting serine/threonine kinase 1 antikoerper, receptor (TNFRSF)-interacting serine-threonine kinase 1 antikoerper, receptor interacting serine/threonine kinase 1 L homeolog antikoerper, RIPK1 antikoerper, Ripk1 antikoerper, ripk1.L antikoerper
    Hintergrund
    RIP (Receptor Interacting Protein) is a 74 kDa Ser/Thr kinase which interacts with CD95 (Fas/Apo1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID, and TRAF2. RIP contains an N-terminal region with homology to protein kinase, an intermediate domain capable of association with MAPKKK and a C-terminal region containing an intracellular death domain motif. RIP activates both p38 MAP kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.Synonyms: Cell death protein RIP, RIPK1, Receptor-Interacting Protein, Receptor-interacting serine/threonine-protein kinase 1, Serine/threonine-protein kinase RIP
    Gen-ID
    8737
    NCBI Accession
    NP_003795
    UniProt
    Q13546
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Ubiquitin Proteasome Pathway
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