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Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.
Authors found that downregulation of HP1alpha (zeige CBX5 Proteine) can decrease H3K9me3 enrichment and DNA methylation (zeige HELLS Proteine) rate of secreted frizzled-related protein 1 (SFRP1) promoter, resulting in restoring the expression of SFRP1.
KL and SFRP1 methylation were more predominant in nasopharyngeal tumors.
Results indicate that SFRP1 rs7832767 C > T, CTNNB1 (zeige CTNNB1 Proteine) rs2293303 C > T, and WISP1 (zeige WISP1 Proteine) rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
miR (zeige MLXIP Proteine)-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.
The expression of Dicer (zeige DICER1 Proteine) negatively correlated with that of SFRP1 and it appeared to promote CCA (zeige FBN2 Proteine) cell proliferation.
H2O2-induced SFRP1 gene demethylation contributes to H2O2-induced apoptosis in human U251 glioma cells.
Data suggest that microRNA miR (zeige MLXIP Proteine)-27a may activate the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway by negatively regulating SFRP1 to promote the proliferation, migration and invasion of breast cancer (BC) cells.
Data indicate that microRNA miR (zeige MLXIP Proteine)-744 activated Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway by targeting multiple negative regulators of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling, including SFRP1, GSK3beta, TLE3 and NKD1 (zeige NKD1 Proteine), and that NKD1 (zeige NKD1 Proteine) is a major functional target of miR (zeige MLXIP Proteine)-744.
Our results indicate that DKK1 (zeige DKK1 Proteine) and SFRP1 may be potentially useful biomarkers for evaluating the beneficial effects of long-term exercise on physical fitness and metabolism as well as the prognosis of patients with cancer.
OVOL1 (zeige OVOL1 Proteine)-regulated Fst (zeige FST Proteine) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (zeige PGR Proteine) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (zeige WNT2 Proteine) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (zeige WNT2 Proteine)/PCP (zeige BMP1 Proteine) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (zeige CASP3 Proteine) expression is decreased, and that p53 (zeige TP53 Proteine) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (zeige WNT3A Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted apoptosis-related protein 2
, secreted frizzled related protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled-related sequence protein 1