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Human Haptoglobin Protein expressed in Human - ABIN3119691
Eshbach, Kaur, Rbaibi, Tejero, Weisz: Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. in American journal of physiology. Cell physiology 2017
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Human Haptoglobin Protein expressed in Human - ABIN491578
Zapotoczna, Heilbronner, Speziale, Foster: Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis. in Journal of bacteriology 2012
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Human Haptoglobin Protein expressed in Human - ABIN3119693
Fatunmbi, Abzalimov, Savinov, Gershenson, Kaltashov: Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry. in Biochemistry 2016
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Suggest a causal relationship between serum Hp levels and macroangiopathy in Chinese type 2 diabetes patients by Mendelian randomization analysis.
findings suggest that rs5471 is a strong genetic determinant of HP levels in Ghanaians, and this seems to be characteristic of Africans
We report on the identification of a novel 72 kd Hb reactive species which is cross-linked to HDL and demonstrate that vitamin E in HDL is decreased in Hp 2-2 diabetes mellitus individuals.
zonulin appears not to be an inflammatory marker in CKD. It seems it also does not play a role in the disturbances of iron metabolism in CKD. Its physiological role remains to be elucidated.
High serum Haptoglobin levels, but not Hp1-Hp2 polymorphism is associated with polycystic ovary syndrome.
Hp 2-2 phenotype is an independent predictor of postoperative acute kidney injury and is associated with decreased short and long-term survival after cardiac surgery in patients with diabetes mellitus.
Due to its fluctuation, a single measurement of zonulin level is not recommended for assessment of intestinal barrier integrity.
Review/Meta-analysis: No association was found between the Hp gene variants and retinopathy in type 2 diabetics.
This study investigates the involvement of Hp glycosylation in gastric cancer. It examined the site-specific glycosylation of serum Hp, revealing the feasibility of glycoproteomic profiling as a powerful platform for potential diagnostic markers with high sensitivity and high specificity for gastric cancer.
Differentially expressed haptoglobin can serve as a potential biomarker for type 2 diabetic mellitus in the American Hispanic population.
identified that apolipoprotein-A1 and haptoglobin had significant predictive values for the prediction of recovery at 12 weeks in DILI, enabling the construction of a new prognostic panel, the DILI-ActiTest, which needs to be independently validated
HP genetic variation may have utility as a biomarker of insulin resistance and diabetes risk in Arab-Americans.
Given the importance of Hp glycosylation, its unknown and unclear biological complexity and significances, Hp glycosylation has become a major target in cancer research. Development of sensitive and specific detection of Hp glycosylation including large-scale validation may be significant steps forward to its clinical application.
Data suggest that serum haptoglobin may act as useful clinical serological biomarkers in progression and prognostic evaluation in non-small cell lung cancer (NSCLC).
Although better control may reduce the incidence of coronary artery disease in Type 1 diabetes, a residual risk related to the haptoglobin 2 allele remains.
Regardless of the haptoglobin genotype, haptoglobin is associated with prevention of endothelial cell apoptosis in diabetes.
study discovered a splice donor founder mutation in HP (NM_001126102.1:c.190 + 1G > C); this mutation occurs on the HP1 allele of the common copy number variant in HP and leads to loss of function of HP1; it associates with lower levels of haptoglobin, higher levels of non-high density lipoprotein cholesterol and greater risk of coronary artery disease
the minor allele (T) of rs8062041 appeared to be protective against African Trypanosomiasis; haptoglobin related protein (HPR) is adjacent to HP and is a component of the Trypanolytic factor; the HP and HPR locus is duplicated in some people; the rs8062041 variant may be associated with this duplication and it is possible that increased production of HPR is the cause of protection associated with rs806204
These results suggest that the hippocampus of Hp 1-1 genetic carriers may be more vulnerable to the insults of poor glycemic control.
Our results show an association between increased early-pregnancy serum zonulin concentration and gestational diabetes, suggesting zonulin as a possible predictor for gestational diabetes.
These results indicate that it is possible to monitor the course of pyometra in cows based on the evaluation of the concentration of cytokines and Hp in the serum and uterine washings.
These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.
An increase in serum amyloid A or haptoglobin in dairy cows with abomasal displacementis not specific for inflammation or bacterial infection; increased levels of either may indicate the presence of hepatic lipidosis.
Haptoglobin concentration may be a useful indicator for cows with postpartum reproductive disorders.
Presence in the milk of the acute phase proteins (APP), haptoglobin (Hp) and serum amyloid A to see the relationships in cow composite and bulk tank milk samples.
Bovine granulocytes, isolated from peripheral blood of healthy cattle, contain abundant amounts of haptoglobin within the granules.
This study suggests that neutrophils and epithelial cells may play an essential role in elevating milk haptoglobin (Hp) in addition to previous suggestions that Hp may be derived from mammary tissues and circulation.
Both immunoblot analyses and enzymelinked immunosorbent assays confirmed the increased concentration of haptoglobin in crude mdx4cv serum. This suggests that haptoglobin, in conjunction with other altered serum proteins, represents a novel diagnostic, prognostic and/or therapymonitoring biomarker candidate to evaluate the inflammatory response in the mdx4cv animal model of dystrophinopathy.
Data show that zonulin-dependent small intestinal barrier impairment is an early step leading to the break of tolerance with subsequent development of chronic inflammatory diseases (CIDs).
the interaction between haptoglobin genotype and vitamin E affects atherosclerotic plaque progression and stability
Exogenous haptoglobin attenuated the HbA-induced HO-1 expression in vitro and in mouse model of sickle cell disease.
Suggest haptoglobin is an enhancer of inflammation after cardiac transplantation, contributing to graft rejection.
Zonulin facilitates development of acute lung injury (ALI) both by enhancing albumin leak and complement activation as well as increased buildup of neutrophils and cytokines during development of ALI.
Haptoglobin deficiency is associated with leakage-prone vessels via isolated VEGFA induction and/or suppressed Ang-1 expression, resulting in unbalanced VEGFalpha/Ang-1 transcription.
Hp generated by the B-cell compartment, rather than by the liver, is functionally contributing to a normal immune response.
the Hp2-2 protein is involved in aneurysm formation and that the Hp genotype may be a useful biomarker in predicting aneurysm progression
Experimental models of colitis showed that haptoglobin has a protective role in inflammatory colitis
these studies provide direct evidence that the increased oxidative stress in Hp 2-2 atherosclerotic plaques is due to hemoglobin derived iron.
Synthetic PPAR gamma ligands selectively activate PPAR gamma bound to the haptoglobin gene promoter to arrest haptoglobin gene transcription.
Hp may be regarded as a regulator of the Th1/Th2 balance in both human and murine immune systems.
Hp plays a pivotal role in reducing renal oxidative damage during haemolysis.
Haptoglobin gene expression regulation
haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis
the haptoglobin gene expression in adipocytes is stimulated by inflammatory cytokines, glucocorticoids, and the sympathetic system
haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in hemochromatosis
a direct linkage between diabetic vascular disease and the Hp genotype.
Increased prevalence of diabetic retinopathy in individuals with the haptoglobin 2 genotype.
crystal structure of the dimeric porcine haptoglobin-haemoglobin complex determined at 2.9 A resolution
This protein is elevated in porcine postweaning multisystemic wasting syndrome.
haptoglobin has a role in oxidative status in piglets undergoing weaning-induced stress
This study suggested closer links between the release of haptoglobin, Pig-MAP and monocytes compared to the release of AGP, SAA and transthyretin.
The haptoglobin was down-regulated with SNPs
Presence of haptoglobin alpha 1S subunit is a reponse to respiratory syndrome virus infection.
results highlight the potential usefulness of Hp as inflammatory marker in horses, showing for the first time the increase of Hp in SF from joint inflammation in the horse
Surfactant protein D and haptoglobin serum concentrations could be a diagnostic aid for equine inflammatory airway disease.
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
, binding peptide
, haptoglobin alpha(1S)-beta
, haptoglobin alpha(2FS)-beta
, haptoglobin, alpha polypeptide
, haptoglobin, beta polypeptide
, liver regeneration-related protein LRRG173
, haptoglobin-related protein
, haptoglobin alpha 1S