Haptoglobin Protein (HP) (AA 145-406) (His tag)

Produktnummer ABIN7318557

Produktdetails

Target: Haptoglobin (HP)

Protein-Typ: Recombinant

Proteineigenschaft: AA 145-406

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Haptoglobin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Haptoglobin/Zonulin Protein (aa 145-406, His Tag)

Sequenz: Cys145-Asn406

Produktmerkmale: Recombinant Human Haptoglobin/Zonulin is produced by our E.coli expression system and the target gene encoding Cys145-Asn406 is expressed with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS,1 mM DTT, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Haptoglobin (HP)

Andere Bezeichnung: Haptoglobin/Zonulin (HP Produkte)

Synonyme: HP Protein, wu:fb64e01 Protein, BP Protein, HP2ALPHA2 Protein, HPA1S Protein, HP-1 Protein, HPR Protein, Zonulin Protein, haptoglobin Protein, haptoglobin-like Protein, HP Protein, hp Protein, Hp Protein, LOC479668 Protein, LOC101102413 Protein

Hintergrund:

Background: Haptoglobin(HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Synonym: Haptoglobin,Zonulin,HP

Molekulargewicht: 31.4 kDa

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis