anti-Maus LBP Antikörper für Functional Studies

Recommended LBP Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Lipopolysaccharide Binding Protein (LBP) Antikörper
  • BPIFD2
  • Bpifd2
  • Ly88
  • LPSBP
  • LBP
  • lipopolysaccharide binding protein
  • lipopolysaccharide-binding protein
  • LBP
  • Lbp
  • LOC100472839
Reaktivität
Maus
83
63
29
11
9
7
4
3
3
2
2
1
Wirt
Ratte
83
37
26
3
Klonalität
Monoklonal
Konjugat
Dieser LBP Antikörper ist unkonjugiert
8
4
3
1
1
1
1
1
1
1
1
1
1
Applikation
Blocking Reagent (BR), Functional Studies (Func), Immunoassay (IA), Western Blotting (WB)
101
73
43
27
17
17
10
9
5
5
4
3
3
3
2
1
1
1
1
1
Optionen
Hersteller
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Produktnummer ABIN2191766
$ 592.77
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
17.260653 ABIN2191765 BR Func IA WB Rat Anmelden zum Anzeigen M330-19 2
12.760653 ABIN343184 Func ELISA Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN603425 Func WB Rat IgG2a Anmelden zum Anzeigen 0
1 ABIN208933 Func ELISA WB Mouse IgG1 Anmelden zum Anzeigen 0
1 ABIN1108025 Func EIA WB Rat IgG2a Anmelden zum Anzeigen M330-19 2
1 ABIN1838034 Func WB Rat IgG2a Anmelden zum Anzeigen M300-19 0
1 ABIN1108027 Func EIA Neut WB Rat IgG2a Anmelden zum Anzeigen M330-19 2
1 ABIN1108024 Func EIA WB Rat IgG2a Anmelden zum Anzeigen RR433-8 2

General

Antigen Lipopolysaccharide Binding Protein (LBP) Antikörper
Reaktivität Maus
(83), (63), (29), (11), (9), (7), (4), (3), (3), (2), (2), (1)
Wirt Ratte
(83), (37), (26), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser LBP Antikörper ist unkonjugiert
(8), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Blocking Reagent (BR), Functional Studies (Func), Immunoassay (IA), Western Blotting (WB)
(101), (73), (43), (27), (17), (17), (10), (9), (5), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-LBP Antikörper

Target Details LBP Anwendungsinformationen Handhabung Referenzen für anti-LBP Antikörper (ABIN2191766) Bilder
Sterilität 0.2 μm filtered
Klon RR433-8
Plasmids, Primers & others

Target Details LBP

Produktdetails anti-LBP Antikörper Anwendungsinformationen Handhabung Referenzen für anti-LBP Antikörper (ABIN2191766) Bilder zurück nach oben
Antigen
Andere Bezeichnung Lipopolysaccharide Binding Protein (LBP Antibody Abstract)
Hintergrund The monoclonal antibody RR433-8 reacts highly specific with mouse natural and recombinant LBP. The antibody is a type II antibody blocking the LPS binding to CD14. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process

Anwendungsinformationen

Produktdetails anti-LBP Antikörper Target Details LBP Handhabung Referenzen für anti-LBP Antikörper (ABIN2191766) Bilder zurück nach oben
Applikations-hinweise For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For neutralization of biological activity dilutions have to be made according to the amounts LBP to be inactivated. Before use in biological assays, the product must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added. Please inquire for availability of azide free solutions.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-LBP Antikörper Target Details LBP Anwendungsinformationen Referenzen für anti-LBP Antikörper (ABIN2191766) Bilder zurück nach oben
Buffer PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Haltbarkeit 12 months

Referenzen für anti-LBP Antikörper (ABIN2191766)

Produktdetails anti-LBP Antikörper Target Details LBP Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Le Roy, Di Padova, Adachi, Glauser, Calandra, Heumann: "Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against gram-negative bacteria." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 5, pp. 2759-65, 2001

Le Roy, Di Padova, Tees, Lengacher, Landmann, Glauser, Calandra, Heumann et al.: "Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7454-60, 1999