anti-Maus Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Antikörper für Immunohistochemistry

Recommended Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) Antikörper
  • zgc:100844
  • IKBKE
  • MGC130907
  • IKK-E
  • IKK-i
  • IKKE
  • IKKI
  • AW558201
  • IKKepsilon
  • Ikki
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog
  • inhibitor of kappaB kinase epsilon
  • IKBKE
  • ikbke
  • ikbke.L
  • Ikbke
Epitop
pSer172
17
15
12
10
10
9
8
7
7
6
6
6
4
3
3
2
1
1
1
1
1
Reaktivität
Human, Maus
117
54
29
2
2
2
2
1
1
1
1
1
Wirt
Kaninchen
108
29
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
116
63
48
21
15
4
4
2
2
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN6271478
$ 450.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
8.404079 ABIN6262509 ELISA IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
8.404079 ABIN2423645 IHC ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
8.404079 ABIN2430295 IHC ELISA Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN3020771 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2887896 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2894313 IHC IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN6040007 ELISA IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN6041001 ELISA IHC Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2934243 ELISA IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1994827 IHC WB Rabbit IgG Anmelden zum Anzeigen 0
1 ABIN3222712 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) Antikörper
Epitop pSer172
(17), (15), (12), (10), (10), (9), (8), (7), (7), (6), (6), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Maus
(117), (54), (29), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Wirt Kaninchen
(108), (29)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(116), (63), (48), (21), (15), (4), (4), (2), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Spezifität IKK-ε (Phospho-Ser172) Antibody detects endogenous levels of IKK-ε only when phosphorylated at Ser172
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human IKK-epsilon (Phospho-Ser172)
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung IKK-epsilon (IKBKE Antibody Abstract)
Hintergrund

Description: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.

Gene: IKBKE

Molekulargewicht 80kDa
Gen-ID 9641
UniProt Q14164
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:1000-3000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (pSer172) antibody (ABIN6271478) ABIN6271479 at 1/200 staining Rat kidney tissue sections by IHC-P. The tissue was for...
Immunohistochemistry (IHC) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (pSer172) antibody (ABIN6271478) ABIN6271479 at 1/200 staining Human kidney tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (pSer172) antibody (ABIN6271478) ABIN6271479 at 1/200 staining Mouse liver tissue sections by IHC-P. The tissue was fo...
Western Blotting (WB) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (pSer172) antibody (ABIN6271478) Western blot analysis IKK-ε (Phospho-Ser172) using Na3VO4 treated HepG2 whole cell ly...