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anti-Human GNAS Antikörper:
anti-Mouse (Murine) GNAS Antikörper:
anti-Rat (Rattus) GNAS Antikörper:
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Cow (Bovine) Polyclonal GNAS Primary Antibody für IHC, WB - ABIN2775542
Bagchi, Wu, French, Kim, Moniri, Daaka: Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells. in Cancer research 2008
Show all 3 Pubmed References
GNAS T/C 393 frequencies were similar in control and PHPT groups. No association was found between genotypes and clinical expression of PHPT. A nonstatistically significant trend was seen to lower BMD (zeige BEST1 Antikörper) in the lumbar spine, femoral neck, and total hip in both PHPT and control C homozygote subjects. A C allele-related susceptibility to lower BMD (zeige BEST1 Antikörper) in trabecular bone in both groups is not enough to suggest more severity.
model suggests Cys1004 in AC6 (zeige ADCY6 Antikörper) (subunit C2) and Cys174 in Galphas present at the AC-Galphas interface as the possible residues that might undergo reversible nitrosylation. Docking analysis predicted novel ligands of AC6 (zeige ADCY6 Antikörper) that include forskolin-based compounds and its derivatives.
In a cohort of patients with pancreatic cysts, KRAS and GNAS mutations had no significant diagnostic benefit in comparison with conventional testing.
High GNAS expression is associated with poor prognosis in intrahepatic cholangiocarcinoma.
we did not observe GNAS or BRAF (zeige BRAF Antikörper) mutations in urachal adenocarcinomas
GNAS mutation is a highly specific test for IPMN. When GNAS testing is added to CEA and KRAS, a significantly greater overall accuracy (86.2%) is achieved.
Our study demonstrates that GNAS mutations are present in a small subset (0.8%) of primary lung carcinomas.
Mutation in GNAS is associated with Albright Hereditary Osteodystrophy.
Both tissue blocks examined were positive for a GNAS p.R201H (c.602G>A) mutation (Fig. 3) at an allele frequency of 4.3 and 9.6%
We now describe a family in which the female proband and her daughter with a maternally inherited 2015-bp deletion that includes GNAS exon 1
The Galphas and Galphaq (zeige GNAQ Antikörper) peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Antikörper), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Antikörper)/Galphaq (zeige GNAQ Antikörper) peptide interactions are predominantly hydrophobic.
Target RNA interference of GNAS in porcine fibroblast cells leads to lower mRNA expression of Bcl-2 (zeige BCL2 Antikörper), Fas (zeige FAS Antikörper), and Caspase-3 (zeige CASP3 Antikörper), which are recognized as apoptosis related markers.
study did not find any significant associations for polymorphisms in insulin (zeige INS Antikörper)-like grwoth factor 2, GTP Binding Protein (zeige RND1 Antikörper) alpha Subunits, Gs and melanocortin receptor 4 (zeige MC4R Antikörper) genes with reproductive traits of Polish Landrace and Large White pigs
Genetic inhibition of GNAS protein in the atrioventricular node reduced heart rate and prevented atrial fibrillation-associated reduction of cardiac function in a porcine model.
Imprinting analysis showed that NESP55 is maternally expressed in young and adult pigs.
Review article on the human GNAS complex locus.
Gsalpha regulates osteoclast differentiation and function through cAMP/PKA and Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathways.
Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Galphas upon receptor activation
This study presents an unexpected proinflammatory switch from Galphas to GalphaI glp1r (zeige GLP1R Antikörper) signaling in burn monocytes which promotes ERK1/2 and NF-kappaB (zeige NFKB1 Antikörper) activation
This study demonstrates that induced expression of the fibrous dysplasia (FD) Galphas mutant from the mouse endogenous Gnas locus exhibits human FD phenotypes in vivo, and that inhibitors of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling may be repurposed for treating FD and other bone diseases caused by Galphas activation.
high osteoblastic GalphaS expression results in aberrant skeletal development in which bone production is favored at the cost of bone quality.
Our findings suggest that a cis (zeige CISH Antikörper)-acting factor could be implicated in reducing paternal Galphas expression in brown adipose tissue
Our data revealed a positive correlation between hepatic Gsalpha-cAMP signal axis and fasting blood glucose (FBG) in slight insulin (zeige INS Antikörper) resistance stage of HIgh Sugar High Fat-diet rats and diabetic db/db (zeige LEPR Antikörper) mice. The current finding thus suggested hepatic Gsalpha-cAMP signal axis plays a central role in regulating of FBG during the developing and development of T2DM.
in colonic crypt cultures, the GLP-1 (zeige GCG Antikörper) secretion induced by such Gq + Gs GPR40 (zeige FFAR1 Antikörper) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
retrograde trafficking to the trans-Golgi network induces local Gs-protein activation and cAMP/PKA signaling at a critical position near the nucleus, which appears required for efficient CREB (zeige CREB1 Antikörper) phosphorylation and gene transcription
results show that most of the PatDp(dist2) phenotype is due to overexpression of Gnasxl combined with loss of expression of Gnas, and suggest that Gnasxl and Gnas may act antagonistically in a number of tissues and to cause a wide range of phenotypic effects
Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.
application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor (zeige ADRB2 Antikörper)
crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor (zeige ADRB2 Antikörper) and nucleotide-free Gs heterotrimer
the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex
a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
adenylate cyclase-stimulating G alpha protein
, alternative gene product encoded by XL-exon
, extra large alphas protein
, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
, guanine nucleotide regulatory protein
, guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
, neuroendocrine secretory protein
, protein ALEX
, secretogranin VI
, GNAS complex locus
, GTP-binding regulatory protein alpha subunit exon 1
, guanine nucleotide binding protein, alpha stimulating activity polypeptide 1
, guanine nucleotide-binding protein G(s) subunit alpha
, stimulatory GTP binding protein
, alpha-stimulatory subunit of GTP-binding protein
, guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1
, Gs alpha subunit
, neuroendocrine secretory protein 55
, stimulatory G-protein alpha subunit
, guanine nucleotide-binding protein G(s) subunit alpha isoforms
, GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
, guanine nucleotide binding protein alpha s
, guanine nucleotide-binding protein G-s, alpha subunit
, guanine nucleotide binding protein, alpha stimulating, olfactory type
, guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like
, Galpha s