GNAS Antikörper (N-Term)

Produktnummer ABIN2775543

Produktdetails anti-GNAS Antikörper

Target: GNAS (GNAS Complex Locus (GNAS))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: SGKSTIVKQM RILHVNGFNG DSEKATKVQD IKNNLKEAIE TIVAAMSNLV

Homologie: Cow: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GNAS. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GNAS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 380 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GNAS

Target: GNAS (GNAS Complex Locus (GNAS))

Andere Bezeichnung: GNAS (GNAS Produkte)

Synonyme: AHO antikoerper, C20orf45 antikoerper, GNAS1 antikoerper, GPSA antikoerper, GSA antikoerper, GSP antikoerper, NESP antikoerper, PHP1A antikoerper, PHP1B antikoerper, PHP1C antikoerper, POH antikoerper, GNAS antikoerper, PORGSA1 antikoerper, G-alpha-S antikoerper, 5530400H20Rik antikoerper, A930027G11Rik antikoerper, C130027O20Rik antikoerper, Galphas antikoerper, Gnas1 antikoerper, Gnasxl antikoerper, Gsa antikoerper, Nesp antikoerper, Nespl antikoerper, Oed-Sml antikoerper, Oedsml antikoerper, P1 antikoerper, P2 antikoerper, P3 antikoerper, G-alpha-s antikoerper, gnas-a antikoerper, Gnpas antikoerper, Nesp55 antikoerper, gnal antikoerper, Gnas antikoerper, GNAS complex locus antikoerper, guanine nucleotide-binding protein G(s) subunit alpha antikoerper, GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus antikoerper, GNAS complex locus S homeolog antikoerper, neuroendocrine secretory protein 55-like antikoerper, GNAS antikoerper, LOC694289 antikoerper, LOC469986 antikoerper, Gnas antikoerper, gnas.S antikoerper, gnas antikoerper, LOC100346323 antikoerper, LOC100442753 antikoerper, LOC100732436 antikoerper

Hintergrund: Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance. There are RefSeqs representing four transcript variants of this gene. Other transcript variants including four additional exons have been described, however, their full length sequences have not been determined.
Alias Symbols: RP4-543J19.4, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, MGC33735, PHP1A, PHP1B, POH, dJ309F20.1.1, dJ806M20.3.3, NESP, PHP1C
Protein Interaction Partner: PANX1, AXIN1, UBC, FUS, OPTN, PTGIR, HLA-A, ADRB2, NUCB2, NUCB1, LAMTOR1, SLC25A12, GNAQ, GNA11, UBD, TBXA2R, GNB1, AVPR2, SUMO1, PCK1, Ric8b, GNG2, CALM1, Haus1, Trim69, Cbx1, RIC8A, TTC1, SNX13, ADCY5, CRHR1, PTGDR, TSHR, CAV3, HTR6, RGS2, ADCY6, VIPR1,
Protein Size: 380

Molekulargewicht: 42 kDa

Gen-ID: 2778

NCBI Accession: NM_080426, NP_536351

UniProt: Q5FWY2

Pathways: Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis