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Results show that regulation of e2f1 (zeige E2F1 Proteine) and PCNA by DREF (zeige ZBED1 Proteine) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A
We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.
E2F (zeige E2F2 Proteine) regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.
A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta (zeige POLD1 Proteine). Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.
tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]
The here presented evidence that the PCNA inner surface is highly regulated to control DNA damage resistance represents a new concept that offers new opportunities to develop tools to manipulate the DNA damage response in cancer treatment. [review]
Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R interacts with and phosphorylates PCNA at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA by RAD18 and SHPRH. (IGF1R = insulin-like growth factor 1 receptor; PCNA = proliferating cell nuclear antigen; RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH = E3 ubiquitin-protein ligase SHPRH)
Here, we report the complex structure of PCNA and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 (zeige UHRF2 Proteine) that contains a PIP (zeige PIP Proteine) box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 (zeige UHRF2 Proteine) by PCNA via PIP (zeige PIP Proteine)-box.
The complex between p15PAF (zeige KIAA0101 Proteine) and trimeric PCNA is of low affinity, forming a transient complex that is difficult to characterize at a structural level due to its inherent polydispersity. We have determined the structure, conformational fluctuations, and relative population of the five species that coexist in solution by combining small-angle X-ray scattering (SAXS) with molecular modelling.
Dynamic binding of the PARG (zeige PARG Proteine) non-canonical PIP (zeige PIP Proteine)-box to PCNA.
PCNA expression significantly associated with clinical stage, histological grade, and poor prognosis of Osteosarcoma, which could evaluate tumor cell proliferation, and predict its biological behavior and prognosis.
High PCNA expression is associated with lung adenocarcinoma.
Eco1 (zeige ESCO1 Proteine) mediated acetylation regulates PCNA sliding on DNA in the presence of DNA damage, favoring homologous recombination linked to sister-chromatid cohesion.
Damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains, previously involved in error-free damage tolerance. Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA damage tolerance.
Multiple studies provide evidence that PCNA lies at the center of the faithful duplication of eukaryotic genomes and therefore genome integrity. [review]
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53 (zeige TP53 Proteine)/PCNA- and ATM (zeige ATM Proteine)/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.
REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (zeige RAD18 Proteine).
PCNA was mainly localized in decidual-stromal cells.
Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 (zeige ICAM1 Proteine) in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.
Data suggest Usp1 (ubiquitin specific peptidase 1) down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2).
The aberrant DNA replication mediated by the PCNA-DNA pol-beta (zeige POLB Proteine) complex induces p53 (zeige TP53 Proteine)-dependent neuronal cell death
Demonstrate that miR (zeige MLXIP Proteine)-376a regulates primordial follicle assembly by modulating the expression of Pcna.
while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers
Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.
This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.
The expression of telomerase activity and TERT (zeige TERT Proteine) in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21 (zeige CDKN1A Proteine), PCNA and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.
There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish
residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates
CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.
PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.
Immunodepletion of Swift PAX-interacting protein 1 (zeige PAXIP1 Proteine) from Xenopus extracts prevented efficient PCNA ubiquitination
PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. Thus, PCNA functions as a platform for Cdt1 destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator.
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
, proliferating cell nuclear antigen
, proliferating-cell nuclear antigen
, DNA polymerase delta auxiliary protein
, proliferating cell nuclear antigen subtype1
, proliferating cell nuclear antigen subtype2
, proliferating cell nuclear antigen subtype3
, proliferative cell nuclear antigen