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Human Polyclonal SMC1A Primary Antibody für ELISA, ICC - ABIN151508
Udayakumar, Bladen, Hudson, Dynan: Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation. in The Journal of biological chemistry 2003
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Human Polyclonal SMC1A Primary Antibody für IP, PLA - ABIN151518
Bekker-Jensen, Lukas, Kitagawa, Melander, Kastan, Bartek, Lukas: Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. in The Journal of cell biology 2006
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Human Polyclonal SMC1A Primary Antibody für ELISA, ICC - ABIN151528
Leung-Pineda, Ryan, Piwnica-Worms: Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. in Molecular and cellular biology 2006
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Human SMC1A Primary Antibody für IHC - ABIN967049
Yang, Mehta, Uzri, Jayaram, Velmurugan: Mutations in a partitioning protein and altered chromatin structure at the partitioning locus prevent cohesin recruitment by the Saccharomyces cerevisiae plasmid and cause plasmid missegregation. in Molecular and cellular biology 2004
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Human Polyclonal SMC1A Primary Antibody für IHC - ABIN967050
Kim, Xu, Kastan: Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. in Genes & development 2002
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Human Monoclonal SMC1A Primary Antibody für FACS, IF - ABIN967048
Kim, Choi, Kim, Woo, Chung: Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes. in FEBS letters 2007
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maintenance of the cancer cell state is dependent on recruitment of Mediator and Cohesin through FOXA and master transcription factors
We conclude that SMC1A variants can result in a phenotype resembling CdLS and a phenotype resembling Rett syndrome. Resemblances between the SMC1A group and the NIPBL group suggest that a disturbed cohesin function contributes to the phenotype, but differences between these groups may also be explained by other underlying mechanisms such as moonlighting of the cohesin genes.
All the nine probands with syndromic craniosynostosis were found to carry the possibly causative variants, among which three variants including two missense mutations in IFT122 (zeige IFT122 Antikörper) gene, in SMC1A gene and a frameshift mutation in TWIST1 (zeige TWIST1 Antikörper) gene have never been reported in patients before.
Based on these findings, LVNC cardiomyopathy and cleft lip should be considered features of SMC1A-associated CdLS (zeige NIPBL Antikörper). All patients should receive echocardiogram and undergo thorough ophthalmologic evaluation as part of routine CdLS (zeige NIPBL Antikörper) care.
Elevated expression of SMC1A in colorectal cancer cells promoted liver metastasis by recruiting the circulating tumor-associated fibroblasts.
This study demonstrated that Truncation mutations in SMC1A cause a severe epilepsy phenotype with cluster seizures in females.
Our data show the existence of a novel phenotypic entity - distinct from Cornelia de Lange syndrome - and caused by de novo SMC1A loss-of-function mutations
We identified a large number of mutations in the CC region of both Smc1 and Smc3 (zeige SMC3 Antikörper)... we introduced them to the yeast Smc1 and Smc3 (zeige SMC3 Antikörper) CC domains and characterized the effect of these mutant alleles on cohesin's function. We identified a missense mutation in the region of the kink domain of Smc3 (zeige SMC3 Antikörper), which was previously identified in kidney carcinoma.
High SMC1A expression is associated with prostate cancer.
Results showed that the high expression of SMC1 often promoted epithelial-mesenchymal transition, accompanied by the enhanced expression of Brachyury (zeige TBX1 Antikörper) in triple-negative breast cancer cells.
zebrafish embryos and SMC1A-mutated pa (zeige NIPBL Antikörper)tient-derived fibroblasts were used to analyze abnormalities induced by SMC1A loss of function
To decipher the functions of the two meiosis-specific kleisins, REC8 or RAD21L, together with the only meiosis-specific SMC protein SMC1b, we generated Smc1b-/-Rec8-/- and Smc1b-/-Rad21L-/- mouse mutants.
expression analysis of Smc1a and Nipbl (zeige NIPBL Antikörper) in developing mouse embryos reveals a specific pattern in the hindbrain
SMC1A participates in tissue-specific enhancer-promoter interactions and interactions that demarcate regions of correlated regulatory output.
Point mutation at the Nbs1 (zeige NBN Antikörper) Threonine 278 site does not affect mouse development, but compromises the Chk2 (zeige CHEK2 Antikörper) and Smc1 phosphorylation after DNA damage.
A positively charged channel within the Smc1/Smc3 (zeige SMC3 Antikörper) hinge required for sister chromatid cohesion.
SMC1alpha is mainly associated with homologous or non-homologous synapsed regions. The protein also localizes along meiotic chromosome cores of Spo11 (zeige SPO11 Antikörper) null spermatocytes.
observations suggest that many of the abnormal stress responses seen in cells lacking ATM (zeige ATM Antikörper), NBS1 (zeige NBN Antikörper), or BRCA1 (zeige BRCA1 Antikörper) result from a failure of ATM (zeige ATM Antikörper) migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation.
SMC1beta (zeige SMC1B Antikörper) was found along the axial elements of synaptonemal complexes in prophase I of testis sections and chromosome spreads . Thus, SMC1beta (zeige SMC1B Antikörper) and not SMC1alpha is likely involved in maintaining cohesion between sister centromeres until anaphase II.
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
SMC protein 1A
, SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
, segregation of mitotic chromosomes 1
, structural maintenance of chromosomes protein 1A
, SMC1 structural maintenance of chromosomes 1-like 1
, structural maintenance of chromosomes 1A
, structural maintenance of chromosomes protein 1A-like
, SMC (segregation of mitotic chromosomes 1)-like 1
, chromosome segregation protein SmcB
, segregation of mitotic chromosomes b
, SMC1 protein cohesin subunit
, structural maintenance of chromosomes 1
, SMC-like 1
, segregation of mitotic chromosomes-like 1
, structural maintenance of chromosomes 1 like 1
, 14S cohesin SMC1 subunit
, structural maintenance of chromosomes 1A a
, LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 1A