SMC1A Antikörper

Produktnummer ABIN7251964

Produktdetails anti-SMC1A Antikörper

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMC1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human SMC1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SMC1A

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Andere Bezeichnung: SMC1A (SMC1A Produkte)

Synonyme: CDLS2 antikoerper, DXS423E antikoerper, SB1.8 antikoerper, SMC1 antikoerper, SMC1L1 antikoerper, SMC1alpha antikoerper, SMCB antikoerper, SMC-1A antikoerper, NV15570 antikoerper, 5830426I24Rik antikoerper, Sb1.8 antikoerper, Smc1 antikoerper, Smc1alpha antikoerper, Smc1l1 antikoerper, Smcb antikoerper, mKIAA0178 antikoerper, smc1 antikoerper, smc1a antikoerper, smc1l1 antikoerper, xSMC1 antikoerper, smc1aa antikoerper, structural maintenance of chromosomes 1A antikoerper, structural maintenance of chromosomes 1A b antikoerper, structural maintenance of chromosomes 1A L homeolog antikoerper, SMC1A antikoerper, smc1a antikoerper, Smc1a antikoerper, smc1ab antikoerper, smc1a.L antikoerper

Hintergrund: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht:

Observed_MW: Refer to figures

Calculated_MW: 143 kDa

UniProt: Q14683

Pathways: Stem Cell Maintenance