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anti-Mouse (Murine) PIWIL2 Antikörper:
anti-Human PIWIL2 Antikörper:
anti-Rat (Rattus) PIWIL2 Antikörper:
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zili might have some effect on the formation of the ectoderm, mesoderm and endoderm during early embryogenesis
Tdrd1 (zeige TDRD1 Antikörper) binds both zebrafish Piwi (zeige PIWIL1 Antikörper) proteins, Ziwi (zeige PIWIL1 Antikörper) and Zili, and reveals sequence specificity in the interaction between Tdrd1 (zeige TDRD1 Antikörper) tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili.
These results indicate that zili regulates dorsal-ventral patterning by antagonizing Bmp signaling during early embryogenesis in zebrafish.
Zebrafish piwil2 is a mediator of Fgf signals in gastrula period.
data presented show that Zili suppresses TGF-beta (zeige TGFB1 Antikörper) signaling by physically associating with Smad4 (zeige SMAD4 Antikörper) and preventing the formation of Smad2 (zeige SMAD2 Antikörper)/3/4 and Smad1 (zeige SMAD1 Antikörper)/5/9/4 complexes
Ziwi (zeige PIWIL1 Antikörper) and Zili bind piRNAs of opposite polarity
When MILI (or PIWIL2), a PIWI family member, was depleted by gene knockout, almost all PIWI-interacting RNA disappeared.
MILI is responsible for DNA methylation (zeige HELLS Antikörper) of a larger subset of TE families than MIWI2 (zeige PIWIL4 Antikörper).
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
Knockdown of MILI in B16 cell line could activate MAGEA expression and increase the cell migration ability, whereas the overexpression of MILI in B16BL6 cell line could inhibit MAGEA expression and decrease the cell migration ability.
Report shows that fly Aub, Bombyx mori Siwi, and mouse MILI select targets bearing a t1A (zeige PDPN Antikörper) nucleotide irrespective of the identity of the g1 nucleotide of their piRNA guide.
Mice with a global deletion of all three piwi (zeige PIWIL1 Antikörper) genes, Miwi (zeige PIWIL1 Antikörper), Mili, and Miwi2 (zeige PIWIL4 Antikörper), are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
The in vitro studies show estrogen can downregulate the expression of miwi (zeige PIWIL1 Antikörper) and mili.
characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1 (zeige PIWIL1 Antikörper)), two Piwi (zeige PIWIL1 Antikörper) proteins expressed in postnatal testis
a new role for Piwil2 in DNA repair
cycles of intra-Mili secondary piRNA biogenesis fuel piRNA amplification that is absolutely required for LINE1 silencing
Results revealed that Piwil2 exhibits 100% positive expression in the cell nucleus, with the intensity higher than in the cytoplasm. Along with nuclear location of PIWIL4 (zeige PIWIL4 Antikörper), PIWIL2 expression is associated with worse prognosis of hepatocellular carcinoma.
this study demonstrates that Piwil2, reactivated by the human papillomavirus oncoproteins E6 and E7, plays an essential role in the transformation of cervical epithelial cells to tumor-initiating cells via epigenetics-based cell reprogramming
Data show that the PIWIL2 protein transfected fibroblast cells grew into tumorous masses within 5 weeks of subcutaneous injection into adult nude mice.
report demonstrated that human Piwil proteins, especially Hili, not only bind to select tRNA species, including rare tRNAs, but also inhibit HIV replication
PIWIL2 and PIWIL4 (zeige PIWIL4 Antikörper) genes expression in synovial fibroblasts of the rheumatoid arthritis patients
MMP9 (zeige MMP9 Antikörper) and PIWIL2 expression levels in cancerous tissues were significantly higher than the adjacent normal tissues
PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (zeige CDK2 Antikörper) and Cyclin A (zeige CCNA2 Antikörper) expression
Piwil 2 expression is correlated with disease-specific and progression-free survival of chemotherapy-treated bladder cancer patients
Univariate analysis demonstrated that high PIWIL2 expression was associated with shorter survival time after radical resection.
Knockdown of Piwil2 gene in SiHa cells inhibited cell growth and invasion, and downregulated matrix metalloproteinase-9 (MMP-9 (zeige MMP9 Antikörper)) compared to scrambled shRNA transfected cells
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003
piwi-like protein 2
, piwi like 2
, Miwi like
, Miwi likw
, piwi like homolog 2
, piwi-like homolog 2
, cancer/testis antigen 80
, piwi-like 2
, piwil2-like protein