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anti-Mouse (Murine) PIWIL2 Antikörper:
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Human Monoclonal PIWIL2 Primary Antibody für IP, ELISA - ABIN532723
Kuramochi-Miyagawa, Kimura, Ijiri, Isobe, Asada, Fujita, Ikawa, Iwai, Okabe, Deng, Lin, Matsuda, Nakano: Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. in Development (Cambridge, England) 2004
Show all 3 Pubmed References
Mouse (Murine) Monoclonal PIWIL2 Primary Antibody für ICC, IF - ABIN2668966
Kirino, Kim, de Planell-Saguer, Khandros, Chiorean, Klein, Rigoutsos, Jongens, Mourelatos: Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. in Nature cell biology 2009
These results suggest that both Olpiwi1 and Olpiwi2 are germ cell specific, and may play important roles in germ cell development and gametogenesis in this model species.
zili might have some effect on the formation of the ectoderm, mesoderm and endoderm during early embryogenesis
Tdrd1 binds both zebrafish Piwi proteins, Ziwi and Zili, and reveals sequence specificity in the interaction between Tdrd1 tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili.
These results indicate that zili regulates dorsal-ventral patterning by antagonizing Bmp signaling during early embryogenesis in zebrafish.
Zebrafish piwil2 is a mediator of Fgf signals in gastrula period.
data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 and preventing the formation of Smad2/3/4 and Smad1/5/9/4 complexes
Ziwi and Zili bind piRNAs of opposite polarity
we show that mitochondria-anchored TDRKH controls multiple steps of pachytene piRNA biogenesis in mice. TDRKH specifically recruits MIWI, but not MILI, to engage the piRNA pathway. It is required for the production of the entire MIWI-bound piRNA population and enables trimming of MILI-bound piRNAs.
When MILI (or PIWIL2), a PIWI family member, was depleted by gene knockout, almost all PIWI-interacting RNA disappeared.
MILI is responsible for DNA methylation of a larger subset of TE families than MIWI2.
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
Knockdown of MILI in B16 cell line could activate MAGEA expression and increase the cell migration ability, whereas the overexpression of MILI in B16BL6 cell line could inhibit MAGEA expression and decrease the cell migration ability.
Report shows that fly Aub, Bombyx mori Siwi, and mouse MILI select targets bearing a t1A nucleotide irrespective of the identity of the g1 nucleotide of their piRNA guide.
Mice with a global deletion of all three piwi genes, Miwi, Mili, and Miwi2, are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
The in vitro studies show estrogen can downregulate the expression of miwi and mili.
characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1), two Piwi proteins expressed in postnatal testis
a new role for Piwil2 in DNA repair
cycles of intra-Mili secondary piRNA biogenesis fuel piRNA amplification that is absolutely required for LINE1 silencing
The results suggest broader roles for Piwil2 in genome surveillance beyond the germ line and a possible role in regulating the cell cycle of mesenchymal stem cells.
Data suggest that the formation of complexes between MILI, MIWI and TDRD1/MTR-1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis.
The Piwil2 protein modulates expression of stem cell specific genes, including Pdgfrb, Slc2a1, Gja7, CD90, Itga6, CD9, Hsp90a, and Stra8.
description of a new class of small RNAs that bind to MILI in mouse male germ cells, where they accumulate at the onset of meiosis
Our observations suggest a conserved function for Piwi-clade proteins in the control of transposons in the germline.
evidence of an adaptive amplification loop in which MILI catalyzes formation of piRNA 5'ends; Mili mutants derepress LINE-1 (L1) & intracisternal A particle & lose DNA methylation of L1 elements, showing conserved role for PIWI in transposon suppression
Data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation of retrotransposons in fetal male germ cells.
MILI may positively regulate translation and that such regulation is required for germ line stem cell self-renewal.
Results suggest that Mili interacts with Tdrd1 in the nuage and chromatoid body, and that this interaction does not contribute to piRNA biogenesis but represents a regulatory mechanism that is critical for spermatogenesis.
Piwi-like 1 and -2 positivity are associated with clinico-pathological factors and survival. Both Piwi-like proteins are suggested as biomarkers for MIBC patients.
Our results showed that HILI suppresses microtubule polymerization and promotes cell proliferation, migration and invasion via TBCB for the first time, revealing a novel mechanism for HILI in tumorigenesis.
Data show that piR-FTH1 (ferritin heavy chain 1) knocks down the Fth1 mRNA via the HIWI2 and HILI mediated mechanism.
PIWILIKE 1 and PIWILIKE 2 mRNA expression exhibited a significant association with impaired sperm characteristics and may be a useful candidate for the evaluation of the impact of PIWILIKE 1-4 mRNA expression on male infertility.
n vitro experiments demonstrated a possible role of the PIWIL2/HILI short isoform in repressing TEs, which could provide a growth advantage for testicular germ cell tumors through securing their genome integrity.
A statistically significantly higher level of PIWIL1 and PIWIL2 was found in IDC compared to mastopathy samples (p=0.0001). Increased expression of PIWIL1 was correlated with increased PIWIL2 expression in breast cancer tissue.
this study shows that an unusual intragenic promoter of PIWIL2 contributes to aberrant activation of oncogenic PL2L60
High expression of PIWIL2 is associated with glioma.
Protein expression levels of PIWIL2 was significantly up-regulated in both papillary and micropapillary thyroid cancers (p<0.01). Moreover, consistent with protein expression levels, mRNA expression levels of PIWIL2 was elevated in both papillary and micropapillary thyroid cancer tissues.
Results revealed that Piwil2 exhibits 100% positive expression in the cell nucleus, with the intensity higher than in the cytoplasm. Along with nuclear location of PIWIL4, PIWIL2 expression is associated with worse prognosis of hepatocellular carcinoma.
this study demonstrates that Piwil2, reactivated by the human papillomavirus oncoproteins E6 and E7, plays an essential role in the transformation of cervical epithelial cells to tumor-initiating cells via epigenetics-based cell reprogramming
Data show that the PIWIL2 protein transfected fibroblast cells grew into tumorous masses within 5 weeks of subcutaneous injection into adult nude mice.
report demonstrated that human Piwil proteins, especially Hili, not only bind to select tRNA species, including rare tRNAs, but also inhibit HIV replication
PIWIL2 and PIWIL4 genes expression in synovial fibroblasts of the rheumatoid arthritis patients
MMP9 and PIWIL2 expression levels in cancerous tissues were significantly higher than the adjacent normal tissues
PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression
Piwil 2 expression is correlated with disease-specific and progression-free survival of chemotherapy-treated bladder cancer patients
Univariate analysis demonstrated that high PIWIL2 expression was associated with shorter survival time after radical resection.
Knockdown of Piwil2 gene in SiHa cells inhibited cell growth and invasion, and downregulated matrix metalloproteinase-9 (MMP-9) compared to scrambled shRNA transfected cells
Results show that both PIWIL2 protein isoforms are expressed in testicular germ cell lines but in the tumors, the short protein and mRNA are predominant and highly expressed in undifferentiated tumors.
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003
piwi-like protein 2
, piwi like 2
, Miwi like
, Miwi likw
, piwi like homolog 2
, piwi-like homolog 2
, cancer/testis antigen 80
, piwi-like 2
, piwil2-like protein