PIWIL2 Antikörper (AA 410-460)

Produktnummer ABIN6991609

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PIWIL2 in WB, ELISA, ICC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für PIWIL2 Antikörper (AA 410-460) (ABIN6991609)

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIWIL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-PIWIL2 Antikörper

Bindungsspezifität: AA 410-460

Spezifität: At least three isoforms of PIWI-L2 are known to exist, this antibody will only detect the two longest isoforms. PIWI-L2 antibody is predicted to not cross-react with other PIWI protein family members.

Aufreinigung: PIWI-L2 Antibody is affinity chromatography purified via peptide column.

Immunogen: PIWI-L2 antibody was raised against a 17 amino acid synthetic peptide near the center of human PIWI-L2. The immunogen is located within amino acids 410 - 460 of PIWI-L2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PIWI-L2 antibody can be used for detection of PIWI-L2 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PIWI-L2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PIWI-L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PIWIL2

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Andere Bezeichnung: PIWI-L2

Hintergrund: PIWI-L2 Antibody: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.

Gen-ID: 55124

NCBI Accession: NP_00129193

UniProt: Q8TC59

Pathways: Stem Cell Maintenance