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Human alpha Actinin 4 Protein expressed in Wheat germ - ABIN1305772
Karlsson, Turkina, Yakymenko, Magnusson, Vikström: The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration. in PLoS pathogens 2012
Human alpha Actinin 4 Protein expressed in HEK-293 Cells - ABIN2714614
Wang, Li, Wang, Tan, Jia, Yang, Li, Shang, Xu, Yang, Shoyama, Cai: Alpha-Actinin-4 is a Possible Target Protein for Aristolochic Acid I in Human Kidney Cells In Vitro. in The American journal of Chinese medicine 2016
ACTN4 is a transcriptional coactivator of NF-kappaB (zeige NFKB1 Proteine).
UCHL1 (zeige UCHL1 Proteine) upregulation in ACTN4-associated FSGS.
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.
Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.
anti-dsDNA Fab (zeige FANCB Proteine) may enhance F-actin formation by the proprietary modification of alpha-actinin-4
Together, these results indicate that alpha-actinin (zeige ACTN1 Proteine) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (zeige AR Proteine).
Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.
newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (zeige NPHS1 Proteine)-supported slit diaphragm complex.
nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement
Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.
Suggest that ACTN4 as a potential predictive biomarker for efficacy of adjuvant chemotherapy in stage-IB/II patients with non-small cell lung cancer, by reflecting the metastatic potential of tumor cells.
High ACTN4 expression is associated with Lung Squamous Cell Carcinoma.
Our findings indicate that ACTN4 promotes EMT (zeige ITK Proteine) and tumorigenesis by regulating Snail (zeige SNAI1 Proteine) expression and the Akt (zeige AKT1 Proteine) pathway in cervical cancer. We propose a novel mechanism for EMT (zeige ITK Proteine) and tumorigenesis in cervical cancer.
Study found a functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis.
SERPINE1 (zeige SERPINE1 Proteine), ANGPLT4, CCL20 (zeige CCL20 Proteine), and SAA1 (zeige SAA1 Proteine) as well as the NF-kappaB (zeige NFKB1 Proteine) (p65 (zeige GORASP1 Proteine)) binding sites on GR-transrepressed promoters such as IL-1beta (zeige IL1B Proteine), IL-6 (zeige IL6 Proteine), and IL-8 (zeige IL8 Proteine) Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.
Here, we report the identification of a novel, disease-causing ACTN4 mutation (p.G195D, de novo) in a sporadic case of childhood FSGS using next generation sequencing.
the calmodulin domain of human alpha-actinin-4 binding to the linker region was important for regulating the distance between actin and actin-binding domain.
This study identified alpha-actinin-4 as a novel NHERF1 (zeige SLC9A3R1 Proteine) interaction partner and provided new insights into the regulatory mechanism of the actin cytoskeleton by NHERF1 (zeige SLC9A3R1 Proteine).
Selective regulation of NF-kappaB (zeige NFKB1 Proteine) gene targets may indicate involvement of ACTN4 in determining the specificity of cell response to NF-kappaB (zeige NFKB1 Proteine) activation in cells of different types. (Review)
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
actinin, alpha 4
, F-actin cross-linking protein
, non-muscle alpha-actinin 4
, alpha actinin 4
, actinin alpha4 isoform
, focal segmental glomerulosclerosis 1