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Human alpha Actinin 4 Protein expressed in Wheat germ - ABIN1305772
Karlsson, Turkina, Yakymenko, Magnusson, Vikström: The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration. in PLoS pathogens 2012
Human alpha Actinin 4 Protein expressed in HEK-293 Cells - ABIN2714614
Wang, Li, Wang, Tan, Jia, Yang, Li, Shang, Xu, Yang, Shoyama, Cai: Alpha-Actinin-4 is a Possible Target Protein for Aristolochic Acid I in Human Kidney Cells In Vitro. in The American journal of Chinese medicine 2016
Focal segmental glomerulosclerosis Actn4 mutation promotes podocyte detachment through maladaptation to periodic stretch.
ACTN4 is a transcriptional coactivator of NF-kappaB (zeige NFKB1 Proteine).
UCHL1 (zeige UCHL1 Proteine) upregulation in ACTN4-associated FSGS.
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.
Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.
anti-dsDNA Fab (zeige FANCB Proteine) may enhance F-actin formation by the proprietary modification of alpha-actinin-4
Together, these results indicate that alpha-actinin (zeige ACTN1 Proteine) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (zeige AR Proteine).
Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.
newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (zeige NPHS1 Proteine)-supported slit diaphragm complex.
Data suggest that TYRO3 (zeige TYRO3 Proteine)-mediated phosphorylation of ACTN4 is involved in invasiveness of melanoma cells; TYRO3 (zeige TYRO3 Proteine)-mediated phosphorylation of ACTN4 requires FAK (zeige PTK2 Proteine) activation at tyrosine 397. (TYRO3 (zeige TYRO3 Proteine) = TYRO3 protein tyrosine kinase (zeige TYRO3 Proteine); ACTN4 = actinin alpha 4; FAK (zeige PTK2 Proteine) = focal adhesion kinase isoform FAK1 (zeige PTK2 Proteine))
ACTN4 knockdown resulted in the blockage of malignant cell proliferation, colony formation, and ameliorated metastasis potency. ACTN4-positive CSCs exhibited a higher ESA (zeige FLOT2 Proteine)(+) proportion, increased mammosphere-formation ability, and enhanced in vivo tumorigenesis ability.
These results demonstrate that both actinin (zeige ACTN1 Proteine)-1 and actinin-4 participate in the assembly of F-actin at invadopodia. Additionally, actinin-4 may have a selective advantage in accelerating invadopodia-mediated invasion of carcinoma cells.
Gene amplification of ACTN4 was a significant independent risk factor for death in patients with stage I/II oral tongue cancer (hazard ratio 6.08, 95% confidence interval 1.66-22.27). Gene amplification of ACTN4 is a potential prognostic biomarker for overall survival in oral tongue cancer.
ACTN4 knockdown near-completely abrogates both radioresistance and epithelial-mesenchymal transition-associated changes in breast cancer cells.
Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.
Suggest that ACTN4 as a potential predictive biomarker for efficacy of adjuvant chemotherapy in stage-IB/II patients with non-small cell lung cancer, by reflecting the metastatic potential of tumor cells.
High ACTN4 expression is associated with Lung Squamous Cell Carcinoma.
Our findings indicate that ACTN4 promotes EMT (zeige ITK Proteine) and tumorigenesis by regulating Snail (zeige SNAI1 Proteine) expression and the Akt (zeige AKT1 Proteine) pathway in cervical cancer. We propose a novel mechanism for EMT (zeige ITK Proteine) and tumorigenesis in cervical cancer.
Study found a functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
actinin, alpha 4
, F-actin cross-linking protein
, non-muscle alpha-actinin 4
, alpha actinin 4
, actinin alpha4 isoform
, focal segmental glomerulosclerosis 1