VEGFR2/CD309 Protein (Fc Tag)

Produktnummer ABIN935901

Produktdetails

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Baculovirus

Aufreinigungstag / Konjugat: Dieses VEGFR2/CD309 Protein ist gelabelt mit Fc Tag.

Produktmerkmale: Purified recombinant Human VEGFR2 protein (Fc Chimera)
Expression System: Baculovirus
Bioactivity: The activity of sVEGFR-2/Fc was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The ED50 for this effect is typically 10-30 ng/mL.

Aufreinigung: Proprietary chromatographic technique

Reinheit: > 90 % pure

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a solution of 1x PBS, pH 7.4.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Antigendetails

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Andere Bezeichnung: VEGFR2 (VEGFR2 Produkte)

Synonyme: CD309 Protein, FLK1 Protein, VEGFR Protein, VEGFR2 Protein, 6130401C07 Protein, Flk-1 Protein, Flk1 Protein, Krd-1 Protein, Ly73 Protein, VEGFR-2 Protein, sVEGFR-2 Protein, Vegfr-2 Protein, FLK-1 Protein, flk-1 Protein, vegfr-2 Protein, KDR Protein, FLK/KDR Protein, flk1 Protein, flk1b Protein, kdrb Protein, si:busm1-205d10.1 Protein, si:ch211-254j6.1 Protein, si:ch211-278f21.4 Protein, wu:fc31a09 Protein, fk52c05 Protein, flk Protein, kdr Protein, kdra Protein, vegfr2 Protein, vegfr4 Protein, vegr2 Protein, wu:fk52c05 Protein, kinase insert domain receptor Protein, kinase insert domain protein receptor Protein, vascular endothelial growth factor receptor kdr-like Protein, kinase insert domain receptor (a type III receptor tyrosine kinase) Protein, kinase insert domain receptor like Protein, KDR Protein, Kdr Protein, LOC100136647 Protein, kdr Protein, kdrl Protein

Sub Type: Fusionprotein

Hintergrund: Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (kDaR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation.Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1).
Alternative Names: VEGFR-2 protein, sKDR D1-7 protein, Protein-tyrosine kinase receptor Flk-1 protein, VEGFR-2 protein, CD309 protein, type III receptor tyrosine kinase protein, D1-7 proteinKDR D1-7 protein, FLK1 protein, KDR protein, Kinase insert domain receptor protein, VEGFR2-Fc Chimera

Molekulargewicht: 160 kDa

Pathways: RTK Signalweg, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling