DDR2 Protein (His tag)

Produktnummer ABIN7533988

Produktdetails

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses DDR2 Protein ist gelabelt mit His tag.

Verwendungszweck: Active Recombinant Human DDR2/CD167b Protein

Sequenz: QVNPAICRYP LGMSGGQIPD EDITASSQWS ESTAAKYGRL DSEEGDGAWC PEIPVEPDDL KEFLQIDLHT LHFITLVGTQ GRHAGGHGIE FAPMYKINYS RDGTRWISWR NRHGKQVLDG NSNPYDIFLK DLEPPIVARF VRFIPVTDHS MNVCMRVELY GCVWLDGLVS YNAPAGQQFV LPGGSIIYLN DSVYDGAVGY SMTEGLGQLT DGVSGLDDFT QTHEYHVWPG YDYVGWRNES ATNGYIEIMF EFDRIRNFTT MKVHCNNMFA KGVKIFKEVQ CYFRSEASEW EPNAISFPLV LDDVNPSARF VTVPLHHRMA SAIKCQYHFA DTWMMFSEIT FQSDAAMYNN SEALPTSPMA PTTYDPMLKV DDSNTR

Spezifität: Gln24-Arg399

Reinheit: > 97 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized Human DDR2 Protein at 1 μg/mL (100 μL/well) can bind DDR2 Rabbit mAb with a linear range of 0.486-33.97 ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Andere Bezeichnung: DDR2/CD167b (DDR2 Produkte)

Synonyme: MIG20a Protein, NTRKR3 Protein, TKT Protein, TYRO10 Protein, AW495251 Protein, Ntrkr3 Protein, tyro10 Protein, DDR2 Protein, Tyro10 Protein, ddr2 Protein, si:ch211-193c2.1 Protein, discoidin domain receptor tyrosine kinase 2 Protein, discoidin domain receptor family, member 2 Protein, discoidin domain receptor family, member 2, like Protein, DDR2 Protein, Ddr2 Protein, ddr2l Protein

Hintergrund:

Description: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Name: DDR2,MIG20a,NTRKR3,TKT,TYRO10, NTRKR3, TKT, TYRO10

Gen-ID: 4921

UniProt: Q16832

Pathways: RTK Signalweg