SARS-CoV-2 Spike Protein (BA.5 - Omicron, Trimer) (His tag)

Produktnummer ABIN7316979

Produktdetails

Target: SARS-CoV-2 Spike

Protein-Typ: Recombinant

Proteineigenschaft: BA.5 - Omicron, Trimer

Spezies: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SARS-CoV-2 Spike Protein ist gelabelt mit His tag.

Verwendungszweck: SARS-CoV-2 Spike Trimer Protein, His Tag (BA.5/Omicron) (Trehalose free) (MALS verified)

Sequenz: Val 16 - Pro 1213

Produktmerkmale: SARS-CoV-2 Spike Trimer, His Tag (BA.5/Omicron) is expressed from human 293 cells (HEK293). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.5, GISAID clade: GRA). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.

Reinheit: 95,00 %

Endotoxin-Niveau: 1.0 EU per μg

Güteklasse: MALS verified

Anwendungsinformationen

Kommentare:

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 137.8 kDa. The protein migrates as 160-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS

Lagerung: -80 °C

Informationen zur Lagerung: -70°C

Antigendetails

Target: SARS-CoV-2 Spike

Abstract: SARS-CoV-2 Spike Produkte

Synonyme: E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein

Hintergrund: Synonyms:Spike,S protein,Spike glycoprotein,S glycoprotein,Description:It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Molekulargewicht: 137.8 kDa