NOTCH3 Protein (AA 40-467) (Fc Tag)

Produktnummer ABIN7275362

Produktdetails

Target: NOTCH3 (Notch 3 (NOTCH3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 40-467

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NOTCH3 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Human Notch 3 Protein

Sequenz: Ala40-Glu467

Produktmerkmale: Recombinant Human Notch 3 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala40-Glu467.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: NOTCH3 (Notch 3 (NOTCH3))

Andere Bezeichnung: Notch 3 (NOTCH3 Produkte)

Synonyme: CADASIL Protein, CASIL Protein, IMF2 Protein, AW229011 Protein, N3 Protein, hpbk Protein, fa14b08 Protein, notch5 Protein, wu:fa14b08 Protein, notch 3 Protein, NOTCH3 Protein, Notch3 Protein, notch3 Protein

Hintergrund: Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs

Molekulargewicht: 71.53 kDa. Due to glycosylation, the protein migrates to 75-83 kDa based on Tris-Bis PAGE result.

UniProt: Q9UM47

Pathways: Notch Signalweg