IL11RA Protein (AA 24-370) (His tag)

Produktnummer ABIN7275012

Produktdetails

Target: IL11RA (Interleukin 11 Receptor, alpha (IL11RA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-370

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL11RA Protein ist gelabelt mit His tag.

Verwendungszweck: Human IL-11R alpha Protein

Sequenz: Ser24-Ala370

Produktmerkmale: Recombinant Human IL-11R alpha Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser24-Ala370.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 1.86 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: IL11RA (Interleukin 11 Receptor, alpha (IL11RA))

Andere Bezeichnung: IL-11R alpha (IL11RA Produkte)

Synonyme: CRSDA Protein, fi26e06 Protein, il-11ra Protein, wu:fi26e06 Protein, AI314697 Protein, GP130 Protein, Il-11ra Protein, Il11ra Protein, Il11ra2 Protein, NR1 Protein, interleukin 11 receptor subunit alpha Protein, interleukin 11 receptor, alpha Protein, interleukin 11 receptor subunit alpha 1 Protein, interleukin 11 receptor, alpha chain 1 Protein, IL11RA Protein, il11ra Protein, Il11ra1 Protein, Il11ra Protein

Hintergrund: Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.

Molekulargewicht: 38.8 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result.

Pathways: JAK-STAT Signalweg, Growth Factor Binding