PVRL2 Protein (Biotin,His-Avi Tag)

Produktnummer ABIN7319914

Produktdetails

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses PVRL2 Protein ist gelabelt mit Biotin,His-Avi Tag.

Verwendungszweck: Recombinant Human PVRL2/Nectin-2/CD112 (C-6His-Avi) Biotinylated

Sequenz: Gln32-Leu360

Produktmerkmale: Biotinylated Recombinant Human Poliovirus Receptor-Related Protein 2 is produced by our Mammalian expression system and the target gene encoding Gln32-Leu360 is expressed with a Avi, 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human PVRIG-mFc(Cat#C08Y) at 10μg/ml (100 μl/well) can bind Biotinylated Human Nectin-2-His-Avi(Cat#CY73). The ED50 of Biotinylated Human Nectin-2-His-Avi(Cat#CY73) is 0.42 ug/ml.

Anwendungsinformationen

Kommentare:

45-60 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Andere Bezeichnung: CD112 (PVRL2 Produkte)

Synonyme: prr2 Protein, AI325026 Protein, AI987993 Protein, Cd112 Protein, MPH Protein, Pvr Protein, Pvs Protein, nectin-2 Protein, CD112 Protein, HVEB Protein, PRR2 Protein, PVRR2 Protein, nectin cell adhesion molecule 2 Protein, Nectin2 Protein, NECTIN2 Protein

Hintergrund:

Background: CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.

Synonym: Poliovirus Receptor-Related Protein 2, Herpes Virus Entry Mediator B, Herpesvirus Entry Mediator B, HveB, Nectin-2, CD112, PVRL2, HVEB, PRR2

Molekulargewicht: 38.4 kDa

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization